Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Detlef Doenecke"'
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e0007243 (2009)
Although ubiquitously present in chromatin, the function of the linker histone subtypes is partly unknown and contradictory studies on their properties have been published. To explore whether the various H1 subtypes have a differential role in the or
Externí odkaz:
https://doaj.org/article/4ad2092604454a459572278aa6c2446f
Autor:
Detlef Doenecke, Nicole Happel
Publikováno v:
Gene. 431:1-12
The lysine-rich H1 histone family in mammals includes eleven different subtypes, and thus it is the most divergent class of histone proteins. The central globular H1 domain asymmetrically interacts with DNA at the exit or entry end of the nucleosomal
Publikováno v:
Experimental Gerontology
Experimental Gerontology, Elsevier, 2008, 43 (3), pp.184. ⟨10.1016/j.exger.2007.11.008⟩
Experimental Gerontology, Elsevier, 2008, 43 (3), pp.184. ⟨10.1016/j.exger.2007.11.008⟩
Until a few years ago, the H1 histones were exclusively considered to be the architectural proteins of chromatin involved in chromatin condensation. However there is now increasing data to support the hypothesis that the H1 subtypes are involved in g
Publikováno v:
Journal of Biological Chemistry. 282:35821-35830
DNA cleavage is a biochemical hallmark of apoptosis. In humans, apoptotic DNA cleavage is executed by DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed in the presence of its chaperone and inhibitor DFF45, which results in
Publikováno v:
Biology of the Cell. 99:541-552
H1 histones are a protein family comprising several subtypes. Although specific functions of the individual subtypes could not be determined so far, differential roles are indicated by varied nuclear distributions as well as differential expression p
Publikováno v:
Journal of Biological Chemistry. 282:10707-10719
The nuclear import of H1 linker histones is mediated by a heterodimer of transport receptors, known as importinbeta and importin7. Interestingly, both importins separately interact with H1, but only as a dimer they facilitate the translocation throug
Autor:
William F. Holmes, Gary S. Stein, Corey D. Braastad, Detlef Doenecke, Werner Albig, Cornelia Hampe, Janet L. Stein, Partha Mitra, Andre J. Van Wijnen
Publikováno v:
Journal of Biological Chemistry. 280:37400-37407
The replication of eukaryotic genomes necessitates the coordination of histone biosynthesis with DNA replication at the onset of S phase. The multiple histone H4 genes encode identical proteins, but their regulatory sequences differ. The contribution
Publikováno v:
Molecular and Cellular Biology. 25:5339-5354
The transcriptional activator NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus present in about 30% of eukaryotic promoters. All three subunits contain evolutionarily conserved core re
Publikováno v:
Biochemical Journal. 384:317-326
We have analysed the transcriptional regulation of the human histone H3 genes using promoter deletion series, scanning mutagenesis, specific mutagenesis and electrophoretic mobility-shift assay experiments. The promoters of five of the six examined h
Publikováno v:
Gene. 312:135-143
Histones are the major protein component of chromatin. Except H4, all histone classes consist of several subtypes. The H3 family includes two replacement histone genes, H3.3A and H3.3B, which both encode the same protein and are expressed independent