Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Detlef, Neumann"'
Autor:
Despoina Kyriazi, Lea Voth, Almke Bader, Wiebke Ewert, Juliane Gerlach, Kerstin Elfrink, Peter Franz, Mariana I. Tsap, Bastian Schirmer, Julia Damiano-Guercio, Falk K. Hartmann, Masina Plenge, Azam Salari, Dennis Schöttelndreier, Katharina Strienke, Nadine Bresch, Claudio Salinas, Herwig O. Gutzeit, Nora Schaumann, Kais Hussein, Heike Bähre, Inga Brüsch, Peter Claus, Detlef Neumann, Manuel H. Taft, Halyna R. Shcherbata, Anaclet Ngezahayo, Martin Bähler, Mahdi Amiri, Hans-Joachim Knölker, Matthias Preller, Georgios Tsiavaliaris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet drug disco
Externí odkaz:
https://doaj.org/article/2b9783ca646c4ead8685a39b451c0553
Autor:
Domiziana Costamagna, Robin Duelen, Fabio Penna, Detlef Neumann, Paola Costelli, Maurilio Sampaolesi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 783-801 (2020)
Abstract Background Anorexia, body wasting, inflammation, muscle, and adipose tissue loss are hallmarks of cancer cachexia, a syndrome that affects the majority of cancer patients, impairing their ability to endure chemotherapeutic therapies and redu
Externí odkaz:
https://doaj.org/article/72d4e09cf61844cebcb3d9037f667760
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Our previous in vitro studies revealed that histamine via histamine the H4-receptors (H4R), as compared to other stimuli, such as eotaxin or formylpeptides, rather partially activates eosinophilic granulocytes (eosinophils). In order to evaluate the
Externí odkaz:
https://doaj.org/article/3e440553c5554c49a88468371c15218b
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Inflammatory bowel diseases (IBD) are a growing health problem worldwide, severely affecting patients’ life qualities and life expectancies. Therapeutic options, which are rare and focus on symptoms associated with the disease, suffer from increasi
Externí odkaz:
https://doaj.org/article/71cc7e39ed824a47be549e6ada07873f
Autor:
Luisa Lindemann, Roland Seifert, Malte Juchem, Kaya Saskia Bittkau, Daniela Bösche, Rukijat Isaev, Detlef Neumann, Bastian Schirmer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:167-174
We hypothesized that, in mice, histamine via the histamine receptor subtype 4 (H4R) on colon epithelial cells affects epithelial barrier integrity, perturbing physiologic function of the colonic mucosa and thus aggravating the severity of colitis. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f92387ac43bb15cad04ff4439a892af
https://doi.org/10.1124/jpet.119.264408
https://doi.org/10.1124/jpet.119.264408
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140173 (2015)
The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression.
Externí odkaz:
https://doaj.org/article/7993f18b25354eb1aa85ed40df6ff48b
Autor:
Detlef Neumann, Bastian Schirmer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6116, p 6116 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e972970dd862eb2f8600d6dd1e78929a
https://www.mdpi.com/1422-0067/22/11/6116
https://www.mdpi.com/1422-0067/22/11/6116
Autor:
Subhashree Mahapatra, Melanie Albrecht, Barbara Behrens, Adan Jirmo, Georg Behrens, Christina Hartwig, Detlef Neumann, Ulrike Raap, Heike Bähre, Christina Herrick, Anna-Maria Dittrich
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87296 (2014)
BACKGROUND: Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of diffe
Externí odkaz:
https://doaj.org/article/60c84e82e82449fdadc707faa5fff2a8
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107481 (2014)
Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro-inflammatory functions. However, their signal transduction pathways have
Externí odkaz:
https://doaj.org/article/16ee79442d3143cdab64fcf53de55747
Autor:
Roland Seifert, Detlef Neumann
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c72a92c949279cc2ec7636d711ff60
https://repository.publisso.de/resource/frl:6447997
https://repository.publisso.de/resource/frl:6447997
