Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Detlef, Balschun"'
Autor:
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta depositi
Externí odkaz:
https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee
Autor:
Alice Uwineza, Ian Cummins, Miguel Jarrin, Alexia A. Kalligeraki, Stephen Barnard, Marco Mol, Genny Degani, Alessandra A. Altomare, Giancarlo Aldini, An Schreurs, Detlef Balschun, Elizabeth A. Ainsbury, Irundika HK Dias, Roy A. Quinlan
Publikováno v:
Advances in Redox Research, Vol 7, Iss , Pp 100057- (2023)
Ionising radiation (IR) is a cause of lipid peroxidation, and epidemiological data have revealed a correlation between exposure to IR and the development of eye lens cataracts. Cataracts remain the leading cause of blindness around the world. The pla
Externí odkaz:
https://doaj.org/article/909a757273cb4520b74c0f1bdaf82b5f
Autor:
Amira Latif-Hernandez, Victor Sabanov, Tariq Ahmed, Katleen Craessaerts, Takashi Saito, Takaomi Saido, Detlef Balschun
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background Intensive basic and preclinical research into Alzheimer’s disease (AD) has yielded important new findings, but they could not yet been translated into effective therapies. One of the reasons is the lack of animal models that suf
Externí odkaz:
https://doaj.org/article/1e4786f2544f436092354c5f169b3626
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Many mouse models of Alzheimer’s disease (AD) exhibit impairments in hippocampal long-term-potentiation (LTP), seemingly corroborating the strong correlation between synaptic loss and cognitive decline reported in human studies. In other A
Externí odkaz:
https://doaj.org/article/8368c7c16d2b4c169e58d858f4711a8b
Autor:
Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blum
Publikováno v:
Neurobiology of Disease, Vol 125, Iss , Pp 14-22 (2019)
Accumulation of hyper-phosphorylated and aggregated Tau proteins is a neuropathological hallmark of Alzheimer's Disease (AD) and Tauopathies. AD patient brains also exhibit insulin resistance. Whereas, under normal physiological conditions insulin si
Externí odkaz:
https://doaj.org/article/1e5dc71246064ca998b489ffffebbd64
Autor:
Tariq Ahmed, Ann Van der Jeugd, Raphaëlle Caillierez, Luc Buée, David Blum, Rudi D’Hooge, Detlef Balschun
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
A major goal in diseases is identifying a potential therapeutic agent that is cost-effective and can remedy some, if not all, disease symptoms. In Alzheimer’s disease (AD), aggregation of hyperphosphorylated tau protein is one of the neuropathologi
Externí odkaz:
https://doaj.org/article/92bf986f882a49b0ac67f35e58e84c5e
Autor:
Claudia Marinangeli, Sébastien Didier, Tariq Ahmed, Raphaelle Caillerez, Manon Domise, Charlotte Laloux, Séverine Bégard, Sébastien Carrier, Morvane Colin, Philippe Marchetti, Bart Ghesquière, Detlef Balschun, Luc Buée, Jérôme Kluza, Valérie Vingtdeux
Publikováno v:
iScience, Vol 9, Iss , Pp 1-13 (2018)
Summary: Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission.
Externí odkaz:
https://doaj.org/article/7580a981d57644c093f4163a9ab04f2b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Neurocognitive disorders, among which Alzheimer’s disease (AD), have become one of the major causes of death in developed countries. No effective disease-modifying therapy is available, possibly because current treatments are administered too late
Externí odkaz:
https://doaj.org/article/4f5be2d041a64410be58cf8a66ef0352
Autor:
Isabel H. Salas, Akila Weerasekera, Tariq Ahmed, Zsuzsanna Callaerts-Vegh, Uwe Himmelreich, Rudi D'Hooge, Detlef Balschun, Takaomi C. Saido, Bart De Strooper, Carlos G. Dotti
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 82-96 (2018)
Type 2 diabetes (T2DM) and obesity might increase the risk for AD by 2-fold. Different attempts to model the effect of diet-induced diabetes on AD pathology in transgenic animal models, resulted in opposite conclusions. Here, we used a novel knock-in
Externí odkaz:
https://doaj.org/article/c03c28b61bb84166ae5f8f5a7191241f
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The hippocampus is important for spatial navigation, episodic memory and affective behaviour. Increasing evidence suggests that these multiple functions are accomplished by different segments along the dorsal-ventral (septal-temporal) axis.
Externí odkaz:
https://doaj.org/article/f3617439a8a6417a8d08e48d8226ec48