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Akademický článek

Influence of pneumatic transportation on the stability of monoclonal antibodies

Autor: Pierre Coliat, Stéphane Erb, Hélène Diemer, Dan Karouby, Tristan Martin, Mainak Banerjee, Chen Zhu, Martin Demarchi, Sarah Cianférani, Alexandre Detappe, Xavier Pivot

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Pneumatic transportation systems (PTS) were recently proposed as a method to carry ready-for-injection diluted monoclonal antibodies (mAbs) from the pharmacy to the bedside of patients. This method reduces transportation time and improves th

Externí odkaz: https://doaj.org/article/2c401a85c3e245a286d2afcfc12de327

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Akademický článek

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

Autor: Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformati

Externí odkaz: https://doaj.org/article/0f5b7e97b6324cda80e7ab7f47fa3f98

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Akademický článek

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction.

Autor: Vaur V; Bio-Functional Chemistry (UMR 7199), Institut du Médicament Strasbourg, University of Strasbourg, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France., Koutsopetras I; Bio-Functional Chemistry (UMR 7199), Institut du Médicament Strasbourg, University of Strasbourg, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France., Erb S; Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.; Infrastructure Nationale de Protéomique ProFI - FR2048, 67087, Strasbourg, France., Jackowska B; Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT9 7BL, U.K., Benazza R; Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.; Infrastructure Nationale de Protéomique ProFI - FR2048, 67087, Strasbourg, France., Cahuzac H; Bio-Functional Chemistry (UMR 7199), Institut du Médicament Strasbourg, University of Strasbourg, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France., Detappe A; Institut de Cancérologie Strasbourg Europe, Strasbourg, France., Hernandez-Alba O; Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.; Infrastructure Nationale de Protéomique ProFI - FR2048, 67087, Strasbourg, France., Cianférani S; Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France.; Infrastructure Nationale de Protéomique ProFI - FR2048, 67087, Strasbourg, France., Scott CJ; Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT9 7BL, U.K., Chaubet G; Bio-Functional Chemistry (UMR 7199), Institut du Médicament Strasbourg, University of Strasbourg, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Oct 01; Vol. 25 (19), pp. e202400170. Date of Electronic Publication: 2024 Jun 26.

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