Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Detao, Gao"'
Autor:
Luyang Xiong, Irina Zhevlakova, Xiaoxia Z West, Detao Gao, Rakhilya Murtazina, Anthony Horak, J Mark Brown, Iuliia Molokotina, Eugene A Podrez, Tatiana V Byzova
Publikováno v:
eLife, Vol 12 (2024)
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintena
Externí odkaz:
https://doaj.org/article/da7dfed429404884b8cd12537ba3b2b8
Autor:
Jared L. Casteel, Kasey R. Keever, Christopher L. Ardell, David L. Williams, Detao Gao, Eugene A. Podrez, Tatiana V. Byzova, Valentin P. Yakubenko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Oxidation of polyunsaturated fatty acids contributes to different aspects of the inflammatory response due to the variety of products generated. Specifically, the oxidation of DHA produces the end-product, carboxyethylpyrrole (CEP), which forms a cov
Externí odkaz:
https://doaj.org/article/6411f6696cbf41a3aa498d72fb16fb1f
Autor:
Mohammad Z. Ashraf, Eugene A. Podrez, Lifang Zhang, Tatiana V. Byzova, Niladri S. Kar, Detao Gao
Publikováno v:
J Biol Chem
Apolipoprotein A-I (apoA-I) is cross-linked and dysfunctional in human atheroma. Although multiple mechanisms of apoA-I cross-linking have been demonstrated in vitro, the in vivo mechanisms of cross-linking are not well-established. We have recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a0c02015413ba55f825a833412b3e8
https://doi.org/10.1074/jbc.ra119.008445
https://doi.org/10.1074/jbc.ra119.008445
Autor:
Luyang Xiong, Michael McCoy, Hitoshi Komuro, Xiaoxia Z. West, Valentin Yakubenko, Detao Gao, Tejasvi Dudiki, Amanda Milo, Jacqueline Chen, Eugene A. Podrez, Bruce Trapp, Tatiana V. Byzova
Publikováno v:
Free Radic Biol Med
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor prognosis and no cure. Substantial evidence implicates inflammation and associated oxidative stress as a potential mechanism for ALS, especially in patients car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f5817cb90dc01c6f3b86fecc03662
https://europepmc.org/articles/PMC8744315/
https://europepmc.org/articles/PMC8744315/
Autor:
Svyatoslav Tkachenko, Tatiana V. Byzova, Eugene A. Podrez, Detao Gao, Michael G. McCoy, Daniel W. Nascimento, Rakhylia Murtazina, Manoj Veleeparambil
Publikováno v:
Sci Signal
Toll-like receptor 2 (TLR2) is implicated in various pathologies, mainly in terms of its function within innate immune cells. However, TLR2 is also present in endothelial cells. Here, we explored the physiological and pathophysiological roles of endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063b53dccb65c717f6cad694c860617f
https://pubmed.ncbi.nlm.nih.gov/34855457
https://pubmed.ncbi.nlm.nih.gov/34855457
Autor:
Jessica Altemus, Umar Rekhi, Tatiana V. Byzova, Eugene A. Podrez, Detao Gao, Sudipta Biswas, Ellen Chang, Maria Febbraio
Publikováno v:
Free Radic Biol Med
CD36 is a multifunctional transmembrane glycoprotein abundantly expressed in several cell types. Recent studies have identified CD36 in circulation (cCD36) in several chronic inflammatory diseases, including type 2 diabetes and chronic kidney disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5b542b63e038534760340b8344c2cc
https://pubmed.ncbi.nlm.nih.gov/33775772
https://pubmed.ncbi.nlm.nih.gov/33775772
Autor:
Eugene A. Podrez, Valentin P. Yakubenko, Xiaoxia Z. West, Kui Cui, Tatiana V. Byzova, Samantha Stefl, Detao Gao, Kathleen E. Brown, Robert G. Salomon, Christopher L. Ardell
Publikováno v:
Blood. 132:78-88
Early stages of inflammation are characterized by extensive oxidative insult by recruited and activated neutrophils. Secretion of peroxidases, including the main enzyme, myeloperoxidase, leads to the generation of reactive oxygen species. We show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bfecabe571dbf3bcf2677f9e97b962e
https://doi.org/10.1182/blood-2017-10-810176
https://doi.org/10.1182/blood-2017-10-810176
Autor:
Robert G. Salomon, Sudipta Biswas, Eugene A. Podrez, Kutralanathan Renganathan, Gabriel B. Gugiu, Tatiana V. Byzova, Valentin P. Yakubenko, Xiaoxia Z. West, Young Woong Kim, Detao Gao, John W. Crabb
Publikováno v:
Circulation Research. 117:321-332
Rationale: Oxidative stress is an important contributing factor in several human pathologies ranging from atherosclerosis to cancer progression; however, the mechanisms underlying tissue protection from oxidation products are poorly understood. Oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f207e4723a8fbed8237003f1a2404b37
https://doi.org/10.1161/circresaha.117.305925
https://doi.org/10.1161/circresaha.117.305925
Autor:
Valentin P, Yakubenko, Kui, Cui, Christopher L, Ardell, Kathleen E, Brown, Xiaoxia Z, West, Detao, Gao, Samantha, Stefl, Robert G, Salomon, Eugene A, Podrez, Tatiana V, Byzova
Publikováno v:
Blood. 132(1)
Early stages of inflammation are characterized by extensive oxidative insult by recruited and activated neutrophils. Secretion of peroxidases, including the main enzyme, myeloperoxidase, leads to the generation of reactive oxygen species. We show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cd409f76eb230989c1a6f9f0ce6d53d
https://pubmed.ncbi.nlm.nih.gov/29976778
https://pubmed.ncbi.nlm.nih.gov/29976778
Publikováno v:
Circulation research. 121(8)
Rationale: Platelet hyperreactivity, which is common in many pathological conditions, is associated with increased atherothrombotic risk. The mechanisms leading to platelet hyperreactivity are complex and not yet fully understood. Objective: Platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dee35ed693e24c083e86d54b199b12
https://pubmed.ncbi.nlm.nih.gov/28775078
https://pubmed.ncbi.nlm.nih.gov/28775078