Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Destiny A. Simpson"'
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216137 (2019)
RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the modified histone H3K4me3, and this interaction is important for relieving inhibition of the RAG
Externí odkaz:
https://doaj.org/article/2a2d99dc63b14c308a30b44ece522a6f
Publikováno v:
Nucleic acids research. 50(20)
In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination activating proteins, RAG1 and RAG2 (RAG1/2), catalyze V(D)J recombination by cleaving adja
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad04abe06ba96f9e43e1912c9740fba
https://pubmed.ncbi.nlm.nih.gov/36370096
https://pubmed.ncbi.nlm.nih.gov/36370096
Autor:
Destiny A Simpson, Karla K. Rodgers
Publikováno v:
The Journal of Immunology. 208:107.13-107.13
The V(D)J recombinase, composed of the recombination activating gene (RAG) proteins, RAG1 and RAG2, generate functional antigen receptor genes through the repeated generation of DNA double strand breaks and DNA repair. However, this process can lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70df4c3be92b6b45dcb87fbd40ddc971
https://doi.org/10.4049/jimmunol.208.supp.107.13
https://doi.org/10.4049/jimmunol.208.supp.107.13
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216137 (2019)
PLoS ONE
PLoS ONE
RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the modified histone H3K4me3, and this interaction is important for relieving inhibition of the RAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb977f8cafc35853701386d84e004bf
https://doaj.org/article/2a2d99dc63b14c308a30b44ece522a6f
https://doaj.org/article/2a2d99dc63b14c308a30b44ece522a6f
Publikováno v:
The Journal of Immunology. 206:107.04-107.04
V(D)J recombination is required to establish the diversity of antigen receptors in the adaptive immune system. Recombination activating gene 2 (RAG2), a protein subunit of the nuclear V(D)J recombinase, rearranges gene segments to generate functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df16224284485afa0513e3f94f06cc04
https://doi.org/10.4049/jimmunol.206.supp.107.04
https://doi.org/10.4049/jimmunol.206.supp.107.04
Publikováno v:
Immunobiology
V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export from the nucleus and enrichment at the centrosome minutes following production of DSBs by g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f59d4643829f714ffa8b773a00fad
https://doi.org/10.1016/j.imbio.2021.152089
https://doi.org/10.1016/j.imbio.2021.152089