Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.

Autor: DeStefano Shields CE; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., White JR; Resphera Biosciences, Baltimore, Maryland., Chung L; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wenzel A; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hicks JL; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Tam AJ; Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Flow Cytometry Technology Development Center, Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chan JL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Dejea CM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Fan H; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Michel J; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland., Maiuri AR; Medical Sciences, Cell, Molecular and Cancer Biology Program, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Bloomington, Indiana., Sriramkumar S; Medical Sciences, Cell, Molecular and Cancer Biology Program, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Bloomington, Indiana., Podicheti R; Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana., Rusch DB; Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana., Wang H; Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., De Marzo AM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Besharati S; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Anders RA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Baylin SB; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland., O'Hagan HM; Medical Sciences, Cell, Molecular and Cancer Biology Program, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Bloomington, Indiana. hmohagan@indiana.edu fhousse1@jhmi.edu csears@jhmi.edu., Housseau F; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. hmohagan@indiana.edu fhousse1@jhmi.edu csears@jhmi.edu.; Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Flow Cytometry Technology Development Center, Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sears CL; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. hmohagan@indiana.edu fhousse1@jhmi.edu csears@jhmi.edu.; Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: Cancer discovery [Cancer Discov] 2021 Jul; Vol. 11 (7), pp. 1792-1807. Date of Electronic Publication: 2021 Feb 25.

Metagenomic analysis of colonic tissue and stool microbiome in patients with colorectal cancer in a South Asian population.

Autor: Gamage, Bawantha Dilshan¹ (AUTHOR) bawantha@sjp.ac.lk, Ranasinghe, Diyanath² (AUTHOR), Sahankumari, AGP¹ (AUTHOR), Malavige, Gathsaurie Neelika² (AUTHOR) gathsaurie.malavige@ndm.ox.ac.uk

Publikováno v: BMC Cancer. 10/9/2024, Vol. 24 Issue 1, p1-12. 12p.

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.

Autor: Gobert AP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States., Al-Greene NT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Singh K; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States., Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, United States., Sierra JC; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States., Verriere TG; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Luis PB; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States., Schneider C; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States., Asim M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Allaman MM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Barry DP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Cleveland JL; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, United States.; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, United States., Destefano Shields CE; Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States., Casero RA Jr; Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States., Washington MK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Piazuelo MB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States., Wilson KT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2018 Jun 05; Vol. 9, pp. 1242. Date of Electronic Publication: 2018 Jun 05 (Print Publication: 2018).

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

Autor: Dejea CM; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Fathi P; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Craig JM; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Boleij A; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Pathology, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, Netherlands., Taddese R; Department of Pathology, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, Netherlands., Geis AL; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Wu X; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., DeStefano Shields CE; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Hechenbleikner EM; Department of Surgery, Johns Hopkins University, Baltimore, MD, USA., Huso DL; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, USA., Anders RA; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Giardiello FM; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Wick EC; Department of Surgery, Johns Hopkins University, Baltimore, MD, USA., Wang H; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Wu S; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Pardoll DM; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Housseau F; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Sears CL; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA. csears@jhmi.edu.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Feb 02; Vol. 359 (6375), pp. 592-597. Date of Electronic Publication: 2018 Feb 01.

Propionate production by Bacteroidia gut bacteria and its dependence on substrate concentrations differs among species.

Autor: Döring, Carolin¹ (AUTHOR), Basen, Mirko^1,2 (AUTHOR) mirko.basen@uni-rostock.de

Publikováno v: Biotechnology for Biofuels & Bioproducts. 7/10/2024, Vol. 17 Issue 1, p1-17. 17p.