Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Dessislava Markova"'
Autor:
Di Chen, Jian Huang, Carla R. Scanzello, Flavia Vitale, Frances S. Shofer, Julie Michelle Brent, Zuozhen Tian, Yejia Zhang, Ling Qin, Lutian Yao, Angela K Brice, Dessislava Markova
Publikováno v:
Comp Med
We showed previously that inflammatory mediators, including IL8, in intervertebral disc tissues from patients with discogenic back pain may play a key role in back pain. To investigate the molecular mechanism of IL8 signaling in back pain, we generat
Autor:
Christopher K. Kepler, Alexander R. Vaccaro, John D Koerner, Joseph Mendelis, Christopher L. Antonacci, D. Greg Anderson, Greg D. Schroeder, Dessislava Markova
Publikováno v:
Neurospine
Neurospine, Vol 17, Iss 1, Pp 36-41 (2020)
Neurospine, Vol 17, Iss 1, Pp 36-41 (2020)
Objective To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration. Methods Intervertebral disc tissue was separated into ann
Autor:
Junmin Hong, Kang Xu, Christopher K. Kepler, Weijian Chen, Jiansen Yan, Dongsheng Huang, Shuangxing Li, Anjing Liang, Yingjie Huang, Dessislava Markova, Wei Ye, Jie Zhou
Publikováno v:
Journal of Cellular Physiology. 235:5736-5749
An imbalance between matrix synthesis and degradation is the hallmark of intervertebral disc degeneration while inflammatory cytokines contribute to the imbalance. Bromodomain and extra-terminal domain (BET) family is associated with the pathogenesis
Autor:
David Greg Anderson, Srikanth N. Divi, Taolin Fang, Alan S. Hilibrand, Christopher K. Kepler, Mark F. Kurd, Ryan Guzek, Dessislava Markova, Alexander R. Vaccaro, Gregory D. Schroeder, Jeffrey A. Rihn
Publikováno v:
Spine. 45(9)
MINI: Circulating microRNAs provide an insight into current disease states. Comparing patients with degenerative disc disease to healthy controls, patients with disc disease were found to have significantly downregulated levels of miR-155-5p. This ma
Autor:
D. Greg Anderson, Alan S. Hilibrand, John D. Koerner, Gregory D. Schroeder, Alexander R. Vaccaro, Dessislava Markova, Christopher K. Kepler, Jeffery A. Rihn
Publikováno v:
Spine. 41:1851-1859
STUDY DESIGN Laboratory study. OBJECTIVE Evaluate the effect of substance P (SP) on an intervertebral disc rat organ culture model. SUMMARY OF BACKGROUND DATA Monolayer cell experiments have demonstrated that exposure intervertebral disc tissue cells
Autor:
Dessislava Markova, Guiyun Zhang, Machiko Arita, Takako Sasaki, David E. Birk, Te-Cheng Pan, Mon-Li Chu, Rui-Zhu Zhang
Publikováno v:
Cell and Tissue Research. 364:637-646
Fibulin-4 is an extracellular matrix glycoprotein essential for elastic fiber formation. Mice deficient in fibulin-4 die perinatally due to severe pulmonary and vascular defects associated with lacking intact elastic fibers. Patients with fibulin-4 m
Autor:
Yingjie Huang, Junmin Hong, Fuxin Wei, Kang Xu, Jianchao Sun, Shuangxing Li, Christopher K. Kepler, Dessislava Markova, Weijian Chen, Wei Ye, Jie Zhou
Publikováno v:
Life sciences. 221
Aims Lower back pain is often associated with intervertebral disc degeneration (IDD), which results from a decrease in nucleus pulposus (NP) cells and an imbalance between the degradation and synthesis of extracellular matrix (ECM) components. Multip
Autor:
Rebecca E. Day, Abbie L. A. Binch, Shilpa S. Gogate, Dessislava Markova, Irving M. Shapiro, Makarand V. Risbud, Ashley Cole, Matthew T. Conner, Zariel I. Johnson, Neil Chiverton, Christine L. Le Maitre
Publikováno v:
Oncotarget
Objectives of this study were to investigate whether AQP1 and AQP5 expression is altered during intervertebral disc degeneration and if hypoxia and HIF-1 regulate their expression in NP cells. AQP expression was measured in human tissues from differe
Autor:
Makarand V. Risbud, Dessislava Markova, Jun Li, Wei Ye, Ye Tian, Jie Zhou, D. Greg Anderson, Irving M. Shapiro
Publikováno v:
The American Journal of Pathology. 185:485-495
We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme in glycosaminoglycan biosynthesis, is responsive to disk degeneration and to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulpo
Autor:
Sherrill L. Adams, Yejia Zhang, Carla R. Scanzello, Greg Anderson, Yan Xiu, Ana Chee, Ling Qin, Miltiadis H. Zgonis, Dessislava Markova, Howard S. An
Publikováno v:
Journal of Orthopaedic Research. 33:556-562
Fibronectin (FN) is a widely expressed molecule that can participate in development of osteoarthritis (OA) affecting cartilage, meniscus, and synovial membrane (SM). The alternatively spliced isoforms of FN in joint tissues other than cartilage have