Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dessislava Malinova"'
Autor:
Laura M. Sanchez, Abigail K. Hopkins, Eduardo Espinosa, Eneko Larrañeta, Dessislava Malinova, Adam Nathan McShane, Juan Domínguez-Robles, Alejandro Rodríguez
Publikováno v:
Chemical and Biological Technologies in Agriculture, Vol 10, Iss 1, Pp 1-11 (2023)
Abstract Background Lignin is a naturally occurring and aromatic biopolymer with well-known antimicrobial and antioxidant properties. Thus, in this work, the use of cellulose nanofibers (CNF) and lignin to produce ultra-light aerogels for biomedical
Externí odkaz:
https://doaj.org/article/e74bfc82210544d4b2d402527536db03
Autor:
Camila J. Picco, Juan Domínguez-Robles, Emilia Utomo, Alejandro J. Paredes, Fabiana Volpe-Zanutto, Dessislava Malinova, Ryan F. Donnelly, Eneko Larrañeta
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1038-1048 (2022)
Implantable drug delivery systems offer an alternative for the treatments of long-term conditions (i.e. schizophrenia, HIV, or Parkinson’s disease among many others). The objective of the present work was to formulate implantable devices loaded wit
Externí odkaz:
https://doaj.org/article/c5b924ef58644e66846979833e963e46
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field. Specific antigens induce B cell activation through the B cell receptor (BCR) which initiates
Externí odkaz:
https://doaj.org/article/6c0451e0964f443791f98080d2995e3c
Publikováno v:
eLife, Vol 8 (2019)
Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto-
Externí odkaz:
https://doaj.org/article/80a5204862284d08adc409cfd600e338
Autor:
Robbert Hoogeboom, Elizabeth M. Natkanski, Carla R. Nowosad, Dessislava Malinova, Rajesh P. Menon, Antonio Casal, Pavel Tolar
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2342-2353 (2018)
Summary: B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa. Here, we show that B cell-specific deletion of the
Externí odkaz:
https://doaj.org/article/ed3e16b70232494090d700da7f95177f
Autor:
Chiara Beilin, Kaushik Choudhuri, Gerben Bouma, Dessislava Malinova, Jaime Llodra, David L. Stokes, Motumu Shimaoka, Timothy A. Springer, Michael L. Dustin, Adrian J. Thrasher, Siobhan O. Burns
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed
Externí odkaz:
https://doaj.org/article/9aa513bc8f90470ea569c3a6faafd9ca
Autor:
Shankha Satpathy, Sebastian A Wagner, Petra Beli, Rajat Gupta, Trine A Kristiansen, Dessislava Malinova, Chiara Francavilla, Pavel Tolar, Gail A Bishop, Bruce S Hostager, Chunaram Choudhary
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 6, Pp 1-22 (2015)
Abstract B‐cell receptor (BCR) signaling is essential for the development and function of B cells; however, the spectrum of proteins involved in BCR signaling is not fully known. Here we used quantitative mass spectrometry‐based proteomics to mon
Externí odkaz:
https://doaj.org/article/6e9e558b60ec42e8b4adc1da130fe1df
Autor:
Camila J. Picco, Emilia Utomo, Andrea McClean, Juan Domínguez-Robles, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Peter E. McKenna, Jonathan G. Acheson, Dessislava Malinova, Ryan F. Donnelly, Eneko Larrañeta
Publikováno v:
Picco, C J, Utomo, E, McClean, A, Domínguez-Robles, J, Kurnia Anjani, Q, Volpe-Zanuto, F, McKenna, P E, Acheson, J G, Malinova, D, Donnelly, R F & Larrañeta, E 2023, ' Development of 3D-printed subcutaneous implants using concentrated polymer/drug solutions ', International Journal of Pharmaceutics, vol. 631, 122477 . https://doi.org/10.1016/j.ijpharm.2022.122477
Implantable drug-eluting devices that provide therapeutic cover over an extended period of time following a single administration have potential to improve the treatment of chronic conditions. These devices eliminate the requirement for regular and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dfce83d97b136a59d2d6f1df97969d
https://doi.org/10.1016/j.ijpharm.2022.122477
https://doi.org/10.1016/j.ijpharm.2022.122477
Endophilin A2 regulates B‐cell endocytosis and is required for germinal center and humoral responses
Autor:
Pavel Tolar, Laabiah Wasim, Rebecca Newman, Ana Martínez-Riaño, Niklas Engels, Dessislava Malinova
Publikováno v:
EMBO Reports
Malinova, D, Wasim, L, Newman, R, Martínez-Riaño, A, Engels, N & Tolar, P 2021, ' Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses ', EMBO Reports, pp. e51328 . https://doi.org/10.15252/embr.202051328
Malinova, D, Wasim, L, Newman, R, Martínez-Riaño, A, Engels, N & Tolar, P 2021, ' Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses ', EMBO Reports, pp. e51328 . https://doi.org/10.15252/embr.202051328
Antigen‐specific B‐cell responses require endosomal trafficking to regulate antigen uptake and presentation to helper T cells, and to control expression and signaling of immune receptors. However, the molecular composition of B‐cell endosomal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6041c88af19b76842e599eaf13f65b
https://doi.org/10.15252/embr.202051328
https://doi.org/10.15252/embr.202051328
Autor:
Beata K. Blaszczyk, Marko Hyvönen, Eileen M. Shore, Anassuya Ramachandran, Pavel Tolar, Diana Carvalho, Chris Jones, Caroline S. Hill, Dessislava Malinova, Laabiah Wasim, Merima Mehić, Ilaria Gori
Publikováno v:
The EMBO Journal
Ramachandran, A, Mehić, M, Wasim, L, Malinova, D, Gori, I, Blaszczyk, B K, Carvalho, D M, Shore, E M, Jones, C, Hyvönen, M, Tolar, P & Hill, C S 2021, ' Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation ', The EMBO Journal . https://doi.org/10.15252/embj.2020106317
Ramachandran, A, Mehić, M, Wasim, L, Malinova, D, Gori, I, Blaszczyk, B K, Carvalho, D M, Shore, E M, Jones, C, Hyvönen, M, Tolar, P & Hill, C S 2021, ' Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation ', The EMBO Journal . https://doi.org/10.15252/embj.2020106317
Fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG) are debilitating diseases that share causal mutations in ACVR1, a TGF‐β family type I receptor. ACVR1R206H is a frequent mutation in both diseases. Pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbceb285c61a07768cad6ed3521d0f31
http://europepmc.org/articles/PMC8280795
http://europepmc.org/articles/PMC8280795