Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Desmond Wai Loon Chin"'
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Autor:
Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong-Jae Shin, Do-Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumor
Externí odkaz:
https://doaj.org/article/3e889e3b0c2349c59ada25c89786da9e
Autor:
Yuji Takihara, Ayako Nakamura-Ishizu, Darren Qiancheng Tan, Masahiro Fukuda, Takayoshi Matsumura, Mitsuhiro Endoh, Yuichiro Arima, Desmond Wai Loon Chin, Terumasa Umemoto, Michihiro Hashimoto, Hidenobu Mizuno, Toshio Suda
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2323-2327 (2019)
Externí odkaz:
https://doaj.org/article/060360589a834657966fc7dbd6b953b1
Autor:
Chelsia Qiuxia Wang, Vaidehi Krishnan, Lavina Sierra Tay, Desmond Wai Loon Chin, Cai Ping Koh, Jing Yuan Chooi, Giselle Sek Suan Nah, Linsen Du, Bindya Jacob, Namiko Yamashita, Soak Kuan Lai, Tuan Zea Tan, Seiichi Mori, Ichiro Tanuichi, Vinay Tergaonkar, Yoshiaki Ito, Motomi Osato
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 767-782 (2014)
The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;R
Externí odkaz:
https://doaj.org/article/3b353b3acf3041a084d54e3e7b53c5e3
Autor:
Francesca Grasso, Sten Eirik W. Jacobsen, Stina Virding Culleton, Tetsuichi Yoshizato, Desmond Wai Loon Chin, Seishi Ogawa, Petter S. Woll, Magdalena Barbachowska
Publikováno v:
Blood. 139:629-634
Chin and colleagues used detailed mutational analysis of aged mice and transplantation to evaluate the mouse as a model of clonal hematopoiesis (CH). Their data suggest that while murine hematopoietic stem cells acquire mutations in CH-associated gen
Autor:
Makiko Mochizuki-Kashio, Deng Jianwen, Toshio Suda, Takayoshi Matsumura, Desmond Wai Loon Chin, Darren Qiancheng Tan, Ayako Nakamura-Ishizu
Publikováno v:
Blood
Hematopoietic stem cells (HSC) rarely divide, rest in quiescence, and proliferate only upon stress hematopoiesis. The cytokine thrombopoietin (Thpo) has been perplexingly described to induce quiescence and promote self-renewal divisions in HSCs. To c
Autor:
Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa
Publikováno v:
Blood. 140:3012-3013
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Autor:
Motomi Osato, Yong-Jae Shin, Jun Zhang, Soo-Chin Lee, Gökhan Cildir, Michelle Meng Huang Mok, Chelsia Qiuxia Wang, Masahito Ikawa, Lih-Wen Deng, Alan Prem Kumar, Liming Chen, Arkasubhra Ghosh, Desmond Wai Loon Chin, Kyaw Ze Ya Maung, Jayantha Gunaratne, Henry Yang, Ekta Khattar, Vinay Tergaonkar, Wei Hong Jeff Chor, Pei Lee, Do-Hyun Nam, Nur Khairiah Mohd-Ismail, Chen Li Chew
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Khattar, E., Maung, K.Z.Y., Chew, C.L. et al. Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. Nat Commun 10, 5349 (2019). https://doi.org/10.1038/s41467-019-13082-9
Increased levels and non-t
Increased levels and non-t
Autor:
Desmond Wai Loon Chin, Ayako Nakamura-Ishizu, A Qilah Banu Bte Abdul Majeed, Toshio Suda, Aled O'Neill, Darren Tan
Publikováno v:
Haematologica
Thrombopoietin has long been known to influence megakaryopoiesis and hematopoietic stem and progenitor cells, although the exact mechanisms through which it acts are unknown. Here we show that MPL expression correlates with megakaryopoietic potential
Autor:
Yuichiro Arima, Masahiro Fukuda, Ayako Nakamura-Ishizu, Toshio Suda, Darren Qiancheng Tan, Desmond Wai Loon Chin, Michihiro Hashimoto, Yuji Takihara, Mitsuhiro Endoh, Hidenobu Mizuno, Terumasa Umemoto, Takayoshi Matsumura
Key Points HSCs can be separated based on high or low mitochondrial mass. Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cce39d5bc9ea38190f257371be14455
https://europepmc.org/articles/PMC6692999/
https://europepmc.org/articles/PMC6692999/
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells
Autor:
Jia Li, Henry Yang, Ayako Nakamura-Ishizu, Ying Li, Chong Yang, Toshio Suda, Darren Qiancheng Tan, Desmond Wai Loon Chin, Shi Hao Tan
Publikováno v:
Cell reports. 26(9)
Protein arginine methyltransferase 5 (PRMT5) is essential for hematopoiesis, while PRMT5 inhibition remains a promising therapeutic strategy against various cancers. Here, we demonstrate that hematopoietic stem cell (HSC) quiescence and viability are