Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Desmond K. W. Lau"'
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Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5
Autor: Mark Okon, Barbara J. Graves, Jedediah J Doane, Frank G. Whitby, Simon L. Currie, Desmond K. W. Lau, Lawrence P. McIntosh
Publikováno v: Nucleic Acids Research
Autoinhibition enables spatial and temporal regulation of cellular processes by coupling protein activity to surrounding conditions, often via protein partnerships or signaling pathways. We report the molecular basis of DNA-binding autoinhibition of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbe2278fed30d6e092b125c992ea864
https://doi.org/10.1093/nar/gkx068
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3
ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain
Autor: Kathleen A. Clark, Kathryn S. Evans, Jedediah J Doane, Simon L. Currie, Niraja Bhachech, Lawrence P. McIntosh, Barbara J. Graves, Jack J. Skalicky, Desmond K. W. Lau, Bethany J. Madison
The recruitment of transcriptional cofactors by sequence-specific transcription factors challenges the basis of high affinity and selective interactions. Extending previous studies that the N-terminal activation domain (AD) of ETV5 interacts with Med
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa40a6644447d021d4ac5a3408c4968
https://doi.org/10.1101/126458
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4
The PNT domain fromDrosophilapointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence
Autor: Lawrence P. McIntosh, Mark Okon, Desmond K. W. Lau
Publikováno v: Protein Science. 21:1716-1725
Pointed-P2, the Drosophila ortholog of human ETS1 and ETS2, is a transcription factor involved in Ras/MAP kinase-regulated gene expression. In addition to a DNA-binding ETS domain, Pointed-P2 contains a PNT (or SAM) domain that serves as a docking mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162d4daf818c1341837ed29aa0361b73
https://doi.org/10.1002/pro.2151
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6
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP
Autor: Adam G. Blaszczak, Barbara J. Graves, Hyun Seo Kang, Gregory M. Lee, Mary L. Nelson, Lawrence P. McIntosh, Desmond K. W. Lau
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 107(22)
Ras/MAPK signaling is often aberrantly activated in human cancers. The downstream effectors are transcription factors, including those encoded by the ETS gene family. Using cell-based assays and biophysical measurements, we have determined the mechan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a8b5509b40caf58e9738503180fa12
https://pubmed.ncbi.nlm.nih.gov/20534573
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7
RPA nucleic acid-binding properties of IFI16-HIN200
Autor: Philippe Youkharibache, Kush Dalal, Benjamin K. Hon, Desmond K. W. Lau, Hongyue Yan, Frederic Pio
Publikováno v: Biochimica et biophysica acta. 1784(7-8)
InterFeron-gamma Inducible protein 16 (IFI16) belongs to the interferon inducible HIN200 protein family that contains transcriptional regulators linked to cell cycle regulation and differentiation. All family members contain at most two domains of 20
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e7fba5793fee4b4e294909ad1ccb50
https://pubmed.ncbi.nlm.nih.gov/18472023
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8
Abstract 1652: Therapeutic targeting of ETS factor ERG for the treatment of prostate cancer
Autor: Huifang Li, Ari Kim, Michael E. Cox, Yubin Guo, Paul S. Rennie, Eric Leblanc, Fariba Ghaidi, Fuqiang Ban, Lawrence P. McIntosh, Michael Hsing, Peter Axerio-Cilies, Desmond K. W. Lau, Miriam S. Butler, Paul M. Yen, Marta Mroczek, Dennis Ma, Scott Lien, Artem Cherkasov, Mani Roshan-Moniri
Publikováno v: Cancer Research. 75:1652-1652
Prostate cancer (PCa) is one of the leading causes of cancer-related death in men worldwide. The common treatment option for recurring and advanced PCa focuses on inhibiting the androgen receptor (AR). Unfortunately, despite an initial response to th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76841ccdb818153198c3ed5adf12d77c
https://doi.org/10.1158/1538-7445.am2015-1652
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9
Abstract 1648: Targeting ETS factor ETV4 as a novel therapeutic for the management of breast and prostate cancer
Autor: Desmond K. W. Lau, Paul M. Yen, Scott Lien, Michael E. Cox, Miriam S. Butler, Paul S. Rennie, Marta Mroczek, Michael Hsing, Fariba Ghaidi, Artem Cherkasov, Eric Leblanc, Mani Roshan Moniri, Lawrence P. McIntosh, Ari Kim
Publikováno v: Cancer Research. 75:1648-1648
Despite the development of several successful targeted therapies, drug resistance and metastasis remain a significant challenge in the treatment of both breast (BCa) and prostate (PCa) cancers. For these reasons, there is an immediate need to identif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::313ad74ecca2041f99854538077188d3
https://doi.org/10.1158/1538-7445.am2015-1648
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10
Structural Characterization of the DAXX N-Terminal Helical Bundle Domain and Its Complex with Rassf1C
Autor: Serena Giovinazzi, Eric Escobar-Cabrera, Lawrence P. McIntosh, Desmond K. W. Lau, Alexander M. Ishov
Publikováno v: Structure. (12):1642-1653
Summary DAXX is a scaffold protein with diverse roles including transcription and cell cycle regulation. Using NMR spectroscopy, we demonstrate that the C-terminal half of DAXX is intrinsically disordered, whereas a folded domain is present near its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbdd6d09637664e139b7b5e7fce2fc6
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