Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Desmond John Best"'
Autor:
Neal Frederick Osborne, J. M. Wilson, Timothy J. Mitchell, Nigel J. P. Broom, Peter J. O'Hanlon, Desmond John Best, Pamela Brown, Robert Cassels
Publikováno v:
Journal of Medicinal Chemistry. 40:2563-2570
The electronic requirements around the C1-C3 region of pseudomonic acid analogues were investigated. Synthetic routes were developed to access a range of compounds where the alpha, beta-unsaturated ester moiety had been replaced by a 5-membered ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c8c0a6f0b463ead739c168eb169393
https://doi.org/10.1021/jm960738k
https://doi.org/10.1021/jm960738k
Autor:
David T. Davies, Desmond John Best, Andrew V. Stachulski, George Burton, Terence C. Smale, Robert Southgate, John S. Elder, Sarah J. Knott, Michael J. Basker
Publikováno v:
The Journal of Antibiotics. 43:574-577
The catecholic acylureido derivative BRL 36650 was the most potent, especially against Pseudomonas aeruginosa strains. We now report on analogues of 1 which either retain a catechol or dihydroxyphenyl unit or contain various catechol isosteres.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cae026828d392eab8d9dd5bf9193fc
https://doi.org/10.7164/antibiotics.43.574
https://doi.org/10.7164/antibiotics.43.574
Autor:
Desmond John Best, Michael J. Basker, Ronald A. Dixon, George Burton, Frank P. Harrington, Kenyon Robert Fletcher, Andrew W. Taylor, Peter H. Bentley, Andrew G. Lashford
Publikováno v:
The Journal of antibiotics. 38(6)
The influence on the antibacterial activity of introducing a 6 alpha-methoxy group into carbenicillin, and various 6 alpha-substituents into sulbenicillin and piperacillin was examined. Further variations of the side chain aryl group were examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e78bafefc0dfd1fc2c4d6175023a56
https://pubmed.ncbi.nlm.nih.gov/3926736
https://pubmed.ncbi.nlm.nih.gov/3926736
Publikováno v:
The Journal of antibiotics. 39(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c4b2dc3c6b0a5a384fec9b8416c885
https://pubmed.ncbi.nlm.nih.gov/3700251
https://pubmed.ncbi.nlm.nih.gov/3700251
Autor:
Kenyon Robert Fletcher, Desmond John Best, Andrew G. Lashford, Ronald A. Dixon, George Burton
Publikováno v:
The Journal of antibiotics. 39(10)
The synthesis and antibacterial activity of 6 alpha-methoxysulbenicillin analogues (2) are described. Structure-activity studies of these derivatives bearing hydrophilic substituents in the phenyl ring led to the identification of disodium 6 beta-[D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8517867b584e89795b6bb2ff5c59bd14
https://pubmed.ncbi.nlm.nih.gov/3096924
https://pubmed.ncbi.nlm.nih.gov/3096924