Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Desmond G. Higgins"'
Autor:
Thomas Schwarzl, Andrea Keogh, Georgina Shaw, Aleksandar Krstic, Elizabeth Clayton, Desmond G. Higgins, Walter Kolch, Frank Barry
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-6 (2023)
Abstract Articular cartilage has only very limited regenerative capacities in humans. Tissue engineering techniques for cartilage damage repair are limited in the production of hyaline cartilage. Mesenchymal stem/stromal cells (MSCs) are multipotent
Externí odkaz:
https://doaj.org/article/7c94cce76ce645939115b06e167c47f5
PDF - 259K, Figure S3. Additional p53 and neuroblastoma prognostic markers overlap data. A. p53 signalling pathway schematic with LiCl differentially regulated genes overlaid, key as in image and as described in Fig. 5B. B. Overlap between IPA predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71cbbadb586951321acdb113f8d49ec5
https://doi.org/10.1158/1535-7163.22500357.v1
https://doi.org/10.1158/1535-7163.22500357.v1
PDF - 61K, Table S3. Alignment scores of GSK3 inhibitor mRNA-seq reads in IMR32 cells with TopHat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598109c00719d31b4da1c7d305e6b975
https://doi.org/10.1158/1535-7163.22500342
https://doi.org/10.1158/1535-7163.22500342
PDF - 122K, Figure S1. Additional expression regulation data. A. Comparison of mRNA-seq and RT-qPCR measurements for the same differentially expressed mRNAs in IMR32 cells upon 24h GSK3 inhibitor treatments. B. Time course of azakenpaullone mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556fe21ae03b5fd8d4713a74ce8bc6f3
https://doi.org/10.1158/1535-7163.22500369.v1
https://doi.org/10.1158/1535-7163.22500369.v1
PDF - 186K, Figure S2. Additional Retinoic Acid (RA) and cell viability. A. The effect of increased RA concentration on MYC mRNA expression in 48h doxycycline and 24h RA treated SY5Y-MYCN cells, assayed by qPCR. B. Time course of NVP-BEZ235 (dual PI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f69e79f7c0478ac092abda44ee0ef69
https://doi.org/10.1158/1535-7163.22500360.v1
https://doi.org/10.1158/1535-7163.22500360.v1
PDF - 98K, Table S2. Flow Cytometry full details in accordance with the MIFlowCyt Standard.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7cf5d901ed2cf8e87114811f10bac7
https://doi.org/10.1158/1535-7163.22500345.v1
https://doi.org/10.1158/1535-7163.22500345.v1
PDF - 219K, Table S1. CAS (Chemical Abstracts Service) numbers, molecular formulas, structures and references for each of the compounds used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fe5238624684f849b584a1155be581
https://doi.org/10.1158/1535-7163.22500348
https://doi.org/10.1158/1535-7163.22500348
PDF - 78K, Figure S4. Additional PFTalpha and GSK3 inhibitor co-treatment viability data. A. Attempted p53 mediated rescue of GSK3 inhibitor cell death phenotype across three cell lines as measured by MTS viability assay after 24h and 48h of treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46436b227ac1d89164227228c0f9314b
https://doi.org/10.1158/1535-7163.22500351
https://doi.org/10.1158/1535-7163.22500351
XLSX - 5959K, Table S4. Gene expression tables and differentially expressed gene lists from GSK3 inhibitor mRNA-seq. A. Gene expression values (CPMkb) for all genes in each sample obtained by mRNA-seq.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04635112299c2d5c1efe2ed4036d1fd4
https://doi.org/10.1158/1535-7163.22500339.v1
https://doi.org/10.1158/1535-7163.22500339.v1
Neuroblastoma is an embryonal tumor accounting for approximately 15% of childhood cancer deaths. There exists a clinical need to identify novel therapeutic targets, particularly for treatment-resistant forms of neuroblastoma. Therefore, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb991681f7da3d0b1a8266d685fa623
https://doi.org/10.1158/1535-7163.c.6536427.v1
https://doi.org/10.1158/1535-7163.c.6536427.v1