Estrogen receptors and their implications in colorectal carcinogenesis

Autor: Francesco eCaiazza, Elizabeth J Ryan, Glen eDoherty, Desmond C Winter, Kieran eSheahan

Publikováno v: Frontiers in Oncology, Vol 5 (2015)

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate intracellular signaling cascades that have important consequences for cellular behavior. Historically linked to carcinogenesis in reproductive organs, estrogens hav

Externí odkaz: https://doaj.org/article/6c014af28fbf4ac29e7de0e143971d96

Depth-dependent differences in community structure of the human colonic microbiota in health.

Autor: Aonghus Lavelle, Grainne Lennon, Neil Docherty, Aine Balfe, Hugh E Mulcahy, Glen Doherty, Diarmuid O Donoghue, John M Hyland, Fergus Shanahan, Kieran Sheahan, J Calvin Coffey, Desmond C Winter, P Ronan O Connell

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78835 (2013)

ObjectiveThe aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional axes.DesignA microbiological protected s

Externí odkaz: https://doaj.org/article/b681a9f9e0c048bb9efebfac0a437464

Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin

Autor: Barry Moran, Conor M Smith, Alexandra Zabarowski, Mark Ryan, Jozsef Karman, Robert W Dunstan, Kathleen M Smith, Roisin Hambly, Jana Musilova, Andreea Petrasca, Aurelie Fabre, Margaret O’Donnell, Karsten Hokamp, Kingston H G Mills, William J Housley, Desmond C Winter, Brian Kirby, Jean M Fletcher

Publikováno v: British Journal of Dermatology.

Background Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients. Despite an incidence of approximately 1%, HS is often underrecognized and underdiagnosed and is associated with a high morbidity and poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6219c38955e10d03cb897e01af28d08
https://doi.org/10.1093/bjd/ljad184

Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment

Autor: Rudi M. H. Roumen, Donald L. van der Peet, Charlotte J L Molenaar, Loes Janssen, Desmond C. Winter, Gerrit D. Slooter

Publikováno v: Molenaar, C J L, Janssen, L, van der Peet, D L, Winter, D C, Roumen, R M H & Slooter, G D 2021, ' Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment ', World Journal of Surgery, vol. 45, no. 7, pp. 2235-2250 . https://doi.org/10.1007/s00268-021-06075-7

Background: Timely treatment for colorectal cancer (CRC) is a quality indicator in oncological care. However, patients with CRC might benefit more from preoperative optimization rather than rapid treatment initiation. The objectives of this study are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa7ed730b2b658e3773d9b127b4d445
https://doi.org/10.1007/s00268-021-06075-7

Updated systematic review of the approach to pelvic exenteration for locally advanced primary rectal cancer

Autor: Matthew R. Fahy, Cathal Hayes, Michael E. Kelly, Desmond C. Winter

Publikováno v: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 48(11)

To review the evidence regarding surgical advances in the management of primary locally advanced rectal cancer.The management of rectal cancer has evolved significantly in recent decades, with improved (neo)adjuvant treatment strategies and enhanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60631d0760dd60b899ff5ef52fc751e
https://pubmed.ncbi.nlm.nih.gov/35031157