Colonisation of the colonic mucus gel layer with butyrogenic and hydrogenotropic bacteria in health and ulcerative colitis

Autor: Helen Earley, Grainne Lennon, J. Calvin Coffey, Desmond C. Winter, P. Ronan O’Connell

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Butyrate is the primary energy source for colonocytes and is essential for mucosal integrity and repair. Butyrate deficiency as a result of colonic dysbiosis is a putative factor in ulcerative colitis (UC). Commensal microbes are butyrogenic

Externí odkaz: https://doaj.org/article/66d0c141823f4f88bf3714160e19779c

Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin

Autor: Barry Moran, Conor M Smith, Alexandra Zabarowski, Mark Ryan, Jozsef Karman, Robert W Dunstan, Kathleen M Smith, Roisin Hambly, Jana Musilova, Andreea Petrasca, Aurelie Fabre, Margaret O’Donnell, Karsten Hokamp, Kingston H G Mills, William J Housley, Desmond C Winter, Brian Kirby, Jean M Fletcher

Publikováno v: British Journal of Dermatology.

Background Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients. Despite an incidence of approximately 1%, HS is often underrecognized and underdiagnosed and is associated with a high morbidity and poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6219c38955e10d03cb897e01af28d08
https://doi.org/10.1093/bjd/ljad184

Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment

Autor: Rudi M. H. Roumen, Donald L. van der Peet, Charlotte J L Molenaar, Loes Janssen, Desmond C. Winter, Gerrit D. Slooter

Publikováno v: Molenaar, C J L, Janssen, L, van der Peet, D L, Winter, D C, Roumen, R M H & Slooter, G D 2021, ' Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment ', World Journal of Surgery, vol. 45, no. 7, pp. 2235-2250 . https://doi.org/10.1007/s00268-021-06075-7

Background: Timely treatment for colorectal cancer (CRC) is a quality indicator in oncological care. However, patients with CRC might benefit more from preoperative optimization rather than rapid treatment initiation. The objectives of this study are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa7ed730b2b658e3773d9b127b4d445
https://doi.org/10.1007/s00268-021-06075-7

Estrogen receptors and their implications in colorectal carcinogenesis

Autor: Francesco eCaiazza, Elizabeth J Ryan, Glen eDoherty, Desmond C Winter, Kieran eSheahan

Publikováno v: Frontiers in Oncology, Vol 5 (2015)

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate intracellular signaling cascades that have important consequences for cellular behavior. Historically linked to carcinogenesis in reproductive organs, estrogens hav

Externí odkaz: https://doaj.org/article/6c014af28fbf4ac29e7de0e143971d96

Open and Endovascular Management of Acute Mesenteric Ischaemia: A Systematic Review

Autor: Desmond C. Winter, B. Murphy, Cornelis H. C. Dejong

Publikováno v: World Journal of Surgery. 43:3224-3231

Background Acute mesenteric ischaemia (AMI) is a life-threatening surgical emergency resulting from thromboembolic occlusion of the mesenteric vasculature. Traditional management of AMI has been open revascularisation with or without bowel resection-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8df85fae8ce6ce8fad91c8f9b425ed
https://doi.org/10.1007/s00268-019-05149-x