Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Desmond A. Brown"'
Autor:
David M. Routman, Ignacio Jusue-Torres, Paul D. Brown, Daniel M. Trifiletti, Sujay A. Vora, Desmond A. Brown, Ian F. Parney, Terry C. Burns, Elizabeth Yan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background and Objectives Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing local con
Externí odkaz:
https://doaj.org/article/3a8126d4f2ad4872bf4d30a5d6f8ce1c
Autor:
Cecile Riviere-Cazaux, Karishma Rajani, Masum Rahman, Juhee Oh, Desmond A. Brown, Jaclyn F. White, Benjamin T. Himes, Ignacio Jusue-Torres, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, William F. Elmquist, Terry C. Burns
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of sur
Externí odkaz:
https://doaj.org/article/b01726b9a3c24b95811a6ea5c664f995
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent gl
Externí odkaz:
https://doaj.org/article/c015455051d141358c38ab0af93970d0
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Karishma Rajani, Amanda Munoz-Casabella, Masum Rahman, Ali Gharibi-Loron, Desmond A. Brown, Kai J. Miller, Jaclyn J. White, Benjamin T. Himes, Ignacio Jusue-Torres, Samar Ikram, Seth C. Ransom, Renee Hirte, Ju-Hee Oh, William F. Elmquist, Jann N. Sarkaria, Rachael A. Vaubel, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, Terry C. Burns
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness. We utilised intra-operative microdialysis to sample the extra
Externí odkaz:
https://doaj.org/article/df7819129fee4a19804cd898e7b157b6
Autor:
Hirokazu Takami, Desmond A. Brown, Joshua A. Spear, Yuki Shinya, Terry C. Burns, Michelle J. Clarke, William E. Krauss
Publikováno v:
World Neurosurgery: X, Vol 21, Iss , Pp 100269- (2024)
Spinal astrocytoma is a rare neoplasm with discouraging prognosis, which accounts for 6–8 % of total intramedullary spinal tumors. As this is a rare entity, details of the clinical and molecular features have not been fully unraveled. We evaluated
Externí odkaz:
https://doaj.org/article/a3aa6cc76c9548f1831540ca273112a8
Autor:
Maxwell T. Laws, Erin N. Walker, Francesca M. Cozzi, Leonel Ampie, Mi-Yeon Jung, Eric C. Burton, Desmond A. Brown
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Glioblastoma is the most common, malignant primary brain tumor in adults and remains universally fatal. While immunotherapy has vastly improved the treatment of several solid cancers, efficacy in glioblastoma is limited. These challenges are due in p
Externí odkaz:
https://doaj.org/article/e1b75d04834e44bca78d4ca7eb854df4
Autor:
Aimee L. Dowling, Stuart Walbridge, Celine Ertekin, Sriya Namagiri, Krystal Camacho, Ashis Chowdhury, Jean-Paul Bryant, Eric Kohut, John D. Heiss, Desmond A. Brown, Sangamesh G. Kumbar, Yeshavanth Kumar Banasavadi-Siddegowda
Publikováno v:
Cells, Vol 12, Iss 21, p 2562 (2023)
Glioblastoma is the most common malignant primary brain tumor. The outcome is dismal, despite the multimodal therapeutic approach that includes surgical resection, followed by radiation and chemotherapy. The quest for novel therapeutic targets to tre
Externí odkaz:
https://doaj.org/article/a2a25bc8c4914f2f9d2697c28c7973a6
Autor:
Benjamin T. Himes, Philipp A. Geiger, Katayoun Ayasoufi, Adip G. Bhargav, Desmond A. Brown, Ian F. Parney
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy has remained largely unchanged in recent years as new therapeutic
Externí odkaz:
https://doaj.org/article/727b372967e7405db471441362f7faf8
Autor:
John P. Welby, Tatiana Kaptzan, Anton Wohl, Timothy E. Peterson, Aditya Raghunathan, Desmond A. Brown, Shiv K. Gupta, Liang Zhang, David J. Daniels
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal tumors foun
Externí odkaz:
https://doaj.org/article/6a3edfbccba04114be7d3293c763114c
Publikováno v:
Case Reports in Neurology, Vol 7, Iss 1, Pp 63-70 (2015)
A 52-year-old male on chronic prednisone for polymyalgia rheumatica presented with a subacute history of headaches, nausea, phonophobia, intermittent diplopia and gait instability. He was hospitalized 2 weeks prior to presentation with extensive eval
Externí odkaz:
https://doaj.org/article/898c632b4f1543429820be0ca691c3c4