Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Desmarini, Desmarini"'
Autor:
Desmarini Desmarini, Guizhen Liu, Henning Jessen, Bethany Bowring, Angela Connolly, Ben Crossett, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens, Cryptococcus neoformans (CnArg1) and Candida albicans (CaIpk2), convey numerous virulence functions, yet it is not known whether the IP3-4K catalytic a
Externí odkaz:
https://doaj.org/article/eafad44c526a4387bcd5b17913ea571e
Autor:
Bethany Grace Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong-Sun Bahn, Seung-Heon Lee, Akio Toh-e, Nicholas Proschogo, Tom Savage, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportuni
Externí odkaz:
https://doaj.org/article/d5ca8be315354e79bcf60f2bea130499
Akademický článek
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Autor:
Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P. Mackay, Jacqueline M. Matthews, Tania C. Sorrell, Sophie Lev, Philip E. Thompson, Julianne Teresa Djordjevic
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1526 (2022)
New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP3 to IP8, provides a promisi
Externí odkaz:
https://doaj.org/article/fe7ab847de6948a7add6e26a15a3fb16
Autor:
Kaufman-Francis, Keren, Djordjevic, Julianne T., Juillard, Pierre-Georges, Lev, Sophie, Desmarini, Desmarini, Grau, Georges E.R., Sorrell, Tania C.
Publikováno v:
In The American Journal of Pathology July 2018 188(7):1653-1665
Autor:
Eamim Daidrê Squizani, Júlia Catarina Vieira Reuwsaat, Sophie Lev, Heryk Motta, Julia Sperotto, Keren Kaufman-Francis, Desmarini Desmarini, Marilene Henning Vainstein, Charley Christian Staats, Julianne T. Djordjevic, Lívia Kmetzsch
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Intracellular calcium (Ca2+) is crucial for signal transduction in Cryptococcus neoformans, the major cause of fatal fungal meningitis. The calcineurin pathway is the only Ca2+-requiring signaling cascade implicated in cryptococcal stress ad
Externí odkaz:
https://doaj.org/article/af512a2c632e48f29809129f84c64afb
Autor:
Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virul
Externí odkaz:
https://doaj.org/article/a8826e64d46d4f19bb5e464319b44f8e
Akademický článek
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Autor:
Sophie Lev, Cecilia Li, Desmarini Desmarini, Tania C. Sorrell, Adolfo Saiardi, Julianne T. Djordjevic
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Invasive fungal pathogens cause more than 300 million serious human infections and 1.6 million deaths per year. A clearer understanding of the mechanisms by which these fungi cause disease is needed to identify novel targets for urgently needed thera
Externí odkaz:
https://doaj.org/article/cf588ad6e1324771ada890c05fa9669c
Autor:
Sophie Lev, Thusitha Rupasinghe, Desmarini Desmarini, Keren Kaufman-Francis, Tania Christine Sorrell, Ute Roessner, Julianne Teresa Djordjevic
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212651 (2019)
The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of g
Externí odkaz:
https://doaj.org/article/f4cd5f35ee78456285e6235bb82dd5aa