Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Desiree Willkommen"'
Autor:
Fabian Maass, Bernhard Michalke, Desiree Willkommen, Andreas Leha, Claudia Schulte, Lars Tönges, Brit Mollenhauer, Claudia Trenkwalder, Daniel Rückamp, Matthias Börger, Inga Zerr, Mathias Bähr, Paul Lingor
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
The aim of the study was to validate a predictive biomarker machine learning model for the classification of Parkinson's disease (PD) and age-matched controls (AMC), based on bioelement abundance in the cerebrospinal fluid (CSF). For this multicentri
Externí odkaz:
https://doaj.org/article/55e016419bec41acbb728d1bc8b630f8
Autor:
Marianna Lucio, Desiree Willkommen, Michael Schroeter, Ali Sigaroudi, Philippe Schmitt-Kopplin, Bernhard Michalke
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Parkinson’s disease (PD) is a neurodegenerative disease with a complex etiology. Several factors are known to contribute to the disease onset and its progression. However, the complete underlying mechanisms are still escaping our understanding. To
Externí odkaz:
https://doaj.org/article/24881a14b1b540f3bf811eea4cff4c88
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Neuronal iron dyshomeostasis occurs in multiple neurodegenerative diseases. Changes in the Fe(II)/Fe(III) ratio toward Fe(II) is closely related to oxidative stress, lipid peroxidation, and represents a hallmark feature of ferroptosis. In particular
Externí odkaz:
https://doaj.org/article/e580f168ac9d46b1964a0f7d5534aca1
Autor:
Desiree Willkommen, Marianna Lucio, Franco Moritz, Sara Forcisi, Basem Kanawati, Kirill S Smirnov, Michael Schroeter, Ali Sigaroudi, Philippe Schmitt-Kopplin, Bernhard Michalke
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208752 (2018)
The underlying mechanisms of Parkinson´s disease are not completely revealed. Especially, early diagnostic biomarkers are lacking. To characterize early pathophysiological events, research is focusing on metabolomics. In this case-control study we i
Externí odkaz:
https://doaj.org/article/49cde44565aa4df68faa6e0318ee6094
Autor:
Inga Zerr, Fabian Maass, Paul Lingor, Bernhard Michalke, Sezgi Canaslan, Mathias Bähr, Matthias Schmitz, Desiree Willkommen
Publikováno v:
Movement disorders 36(12), 2967-2969 (2021). doi:10.1002/mds.28790
Longitudinal PD CSF samples were subjected to ICP-MS and the total amount of iron and other bioelements was quantified. Additionally, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd5f2d680b0318b9fb8fbff8d2f5c10
https://doi.org/10.1002/mds.28790
https://doi.org/10.1002/mds.28790
Publikováno v:
J. Vis. Exp.:e61055 (2020)
Dyshomeostasis of iron metabolism is accounted in the pathophysiological framework of numerous diseases, including cancer and several neurodegenerative conditions. Excessive iron results in free redox-active Fe(II) and can cause devastating effects w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad920ba8ab9133f8caa357ed54dcb64
https://doi.org/10.3791/61055-v
https://doi.org/10.3791/61055-v
Autor:
Desiree Willkommen, Fabian Maass, Bernhard Michalke, Inga Zerr, Matthias Boerger, Lars Tönges, Paul Lingor, Claudia Schulte, Mathias Bähr
Publikováno v:
Journal of trace elements in medicine and biology 57, 126412 (2020). doi:10.1016/j.jtemb.2019.126412
The aim of the study was to investigate if speciation analysis by liquid chromatography coupled to mass spectrometry could be used to detect organic and inorganic binding forms of selenium in the cerebrospinal fluid (CSF) of patients with Parkinson's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630600b936d3d780c3e028ac8fd0e213
Autor:
Thorsten R. Doeppner, Ashley I. Bush, Xudong Huang, Vivek Venkataramani, Yongjuan Xin, Guilin Ye, Ho Yu Au-Yeung, Debomoy K. Lahiri, Allegra T. Aron, Jack T. Rogers, Bernhard Michalke, Yanyan Liu, Desiree Willkommen, Gerald Wulf, Philipp Ströbel, Fudi Wang, Adam Southon, Catherine M. Cahill
Publikováno v:
Journal of Neurochemistry. 147:831-848
For more than 150 years, it is known that occupational overexposure of manganese (Mn) causes movement disorders resembling Parkinson's disease (PD) and PD-like syndromes. However, the mechanisms of Mn toxicity are still poorly understood. Here, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19243fada200121353f2e39ff42b7211
https://doi.org/10.1111/jnc.14580
https://doi.org/10.1111/jnc.14580
Publikováno v:
Trends Analyt. Chem. 104, 160-170 (2017)
Element speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic latera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602e0a284f036640723529585754eff0
https://doi.org/10.1016/j.trac.2017.08.008
https://doi.org/10.1016/j.trac.2017.08.008
Autor:
Fabian Maass, Desiree Willkommen, Matthias Börger, Inga Zerr, Daniel Rückamp, Lars Tönges, Brit Mollenhauer, Paul Lingor, Andreas Leha, Claudia Trenkwalder, Claudia Schulte, Bernhard Michalke, Mathias Bähr
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiology of disease 134, 104677 (2020). doi:10.1016/j.nbd.2019.104677
Neurobiology of disease 134, 104677 (2020). doi:10.1016/j.nbd.2019.104677
The aim of the study was to validate a predictive biomarker machine learning model for the classification of Parkinson's disease (PD) and age-matched controls (AMC), based on bioelement abundance in the cerebrospinal fluid (CSF). For this multicentri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948431bdcbd39156f3f8d8cce05cfa03
https://mediatum.ub.tum.de/doc/1553860/document.pdf
https://mediatum.ub.tum.de/doc/1553860/document.pdf