Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Desiree Piscitello"'
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Purpose:DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a29580a46fcfef7222e607e4a72eeb9
https://doi.org/10.1158/1078-0432.c.6533180.v2
https://doi.org/10.1158/1078-0432.c.6533180.v2
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Accompanies Figure 3 (Effect of ART558 under hypoxic conditions)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78beef4f4c5fd7b17ac4512774531dee
https://doi.org/10.1158/1078-0432.22633127.v1
https://doi.org/10.1158/1078-0432.22633127.v1
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Accompanies Figure 2 (ART558 treatment leads to increased residual IR-induced DNA damage foci)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db96bdfa7ff65e6f514c4d6f5f217e4
https://doi.org/10.1158/1078-0432.22633130
https://doi.org/10.1158/1078-0432.22633130
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Distribution of POLQ mRNA levels across cell lines from CCLE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650843f62e928bbfa3d35aff57633f4a
https://doi.org/10.1158/1078-0432.22633136
https://doi.org/10.1158/1078-0432.22633136
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Accompanies Figure 4 (Characterization of ART899 as a specific and potent Polθ inhibitor with improved stability)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8087d60802e6f406ed2d1dc76ee709c
https://doi.org/10.1158/1078-0432.22633124
https://doi.org/10.1158/1078-0432.22633124
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Accompanies Figure 5 (ART899 combined with radiation causes significant tumor growth delay in vivo and is well tolerated)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8542db58a4675723164101ab1424296
https://doi.org/10.1158/1078-0432.22633121
https://doi.org/10.1158/1078-0432.22633121
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Luciferase-based MMEJ assay in a panel of cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ee8d2a1af03b4bfa1cc9cb9bc0e235
https://doi.org/10.1158/1078-0432.22490558.v1
https://doi.org/10.1158/1078-0432.22490558.v1
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Cell cycle-dependent effects of ART558 in combination with IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e05d2df5474d017c1948a3ec5a4511
https://doi.org/10.1158/1078-0432.22490576
https://doi.org/10.1158/1078-0432.22490576
Autor:
Gonzalo Rodriguez-Berriguete, Marco Ranzani, Remko Prevo, Rathi Puliyadi, Nicole Machado, Hannah R. Bolland, Val Millar, Daniel Ebner, Marie Boursier, Aurora Cerutti, Alessandro Cicconi, Alessandro Galbiati, Diego Grande, Vera Grinkevich, Jayesh B. Majithiya, Desiree Piscitello, Eeson Rajendra, Martin L. Stockley, Simon J. Boulton, Ester M. Hammond, Robert A. Heald, Graeme C.M. Smith, Helen M.R. Robinson, Geoff S. Higgins
Purpose: DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb60d7a1b512505cda162e094f90f72
https://doi.org/10.1101/2022.09.27.509658
https://doi.org/10.1101/2022.09.27.509658
Autor:
Manish Patel, Kathleen N. Moore, Desiree Piscitello, Jayesh Majithiya, Marina Roy Luzarraga, Helen Millward, Sarah V. Holt, Melissa Johnson
Publikováno v:
Cancer Research. 82:LB520-LB520
Inhibition of ataxia telangiectasia and Rad-3 related (ATR) kinase offers therapeutic promise for DNA damage response deficient tumors. In addition, ATR inhibitors may offer even broader clinical utility when combined with PARPi’s, chemo, immune or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8339b39988ac45f52409a44d9375f61f
https://doi.org/10.1158/1538-7445.am2022-lb520
https://doi.org/10.1158/1538-7445.am2022-lb520
