Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Desiree M. Baron"'
Autor:
Desiree M. Baron, Adam R. Fenton, Sara Saez-Atienzar, Anthony Giampetruzzi, Aparna Sreeram, Shankaracharya, Pamela J. Keagle, Victoria R. Doocy, Nathan J. Smith, Eric W. Danielson, Megan Andresano, Mary C. McCormack, Jaqueline Garcia, Valérie Bercier, Ludo Van Den Bosch, Jonathan R. Brent, Claudia Fallini, Bryan J. Traynor, Erika L.F. Holzbaur, John E. Landers
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110598- (2022)
Summary: Understanding the pathogenic mechanisms of disease mutations is critical to advancing treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A result in skipping of exon 27 (KIF5AΔExon27) and the encoding of a p
Externí odkaz:
https://doaj.org/article/41f4ac2c79914783b41ee67f3202e865
Autor:
Maeve Tischbein, Yen-Chen Lin, Katherine V. Gall, Daryl A. Bosco, Claudia Fallini, John Landers, Desiree M. Baron
Publikováno v:
J Biol Chem
Excitotoxic levels of glutamate represent a physiological stress that is strongly linked to amyotrophic lateral sclerosis (ALS) and other neurological disorders. Emerging evidence indicates a role for neurodegenerative disease–linked RNA-binding pr
Autor:
Yen-Chen Lin, John D. Leszyk, Evangelos Kiskinis, John Landers, Salome Funes, Lawrence J. Hayward, Scott A. Shaffer, Maeve Tischbein, Kevin P. Kenna, Roy Parker, Tyler Matheny, Desiree M. Baron, Daryl A. Bosco, David Santos, Katherine V. Gall
Publikováno v:
Hum Mol Genet
Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired stress responses in neurodegeneration. However, our knowledge of th
Autor:
Claudia Fallini, Desiree M. Baron, Yen-Chen Lin, Daryl A. Bosco, Katherine V. Gall, Maeve Tischbein, John Landers
Excitotoxic levels of glutamate represent a physiological stress that is strongly linked to amyotrophic lateral sclerosis (ALS) and other neurological disorders. Emerging evidence indicates a role for neurodegenerative disease linked RNA-binding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80989f083ede9d9ec765013c3b19ddfc
Autor:
Desiree M. Baron, Max Koppers, Gary J. Bassell, Andrew Fox, Elizabeth T. Cirulli, Chi Hong Wu, Dev Mangroo, Zuoshang Xu, Jill A. Zitzewitz, Cinzia Gellera, David Goldstein, John Landers, Vivian E. Drory, Diane McKenna-Yasek, François Salachas, Wilfried Rossoll, Paloma Gonzalez-Perez, Robert H. Brown, Katarzyna Piotrowska, Leonard H. van den Berg, Ashley Lyn Leclerc, Patrick Lowe, Franco Taroni, Pamela Keagle, Jenni Adams, Peter C. Sapp, Shawn C. Chafe, Claudia Fallini, Nicola Ticozzi, Antonia Ratti, Jonathan D. Glass, Vincenzo Silani, Gabriele Siciliano, Jason E. Kost, Melissa J. Moore, Cinzia Tiloca, Daryl A. Bosco, Vincent Meininger
Publikováno v:
Nature
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Approximately 10% of cases are familial (FALS), typically with a dominant inheritance mode. Despite numerous advances in recent years1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45572b386855a800145761a0b8d1fa61
http://hdl.handle.net/11568/156468
http://hdl.handle.net/11568/156468
Publikováno v:
Journal of cell science. 120(Pt 9)
Axonemal dyneins are multisubunit molecular motors that provide the driving force for flagellar motility. Dynein light chain 1 (LC1) has been well studied in Chlamydomonas reinhardtii and is unique among all dynein components as the only protein know
Publikováno v:
Journal of cell science. 120(Pt 3)
Cilia and flagella are highly conserved, complex organelles involved in a variety of important functions. Flagella are required for motility of several human pathogens and ciliary defects lead to a variety of fatal and debilitating human diseases. Ma
Autor:
Reddy Ranjith Kumar Sama, Daryl A. Bosco, Desiree M. Baron, Catherine L. Ward, Laura J. Kaushansky, Alexandre J.C. Quaresma, Kristin J. Boggio, Ru-ju Chian, Jeffrey A. Nickerson
Publikováno v:
Molecular Neurodegeneration
Background Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. Since only the mutants, but not the endogenous