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pro vyhledávání: '"Desiree Kaufmann"'
Autor:
Ajay Abisheck Paul George, Pascal Heimer, Enrico Leipold, Thomas Schmitz, Desiree Kaufmann, Daniel Tietze, Stefan H. Heinemann, Diana Imhof
Publikováno v:
Marine Drugs, Vol 17, Iss 7, p 390 (2019)
Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel NaV1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simulations bas
Externí odkaz:
https://doaj.org/article/32742123ecf1403585f3326f2a9638c7
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 180 (2019)
Understanding subtype specific ion channel pore blockage by natural peptide-based toxins is crucial for developing such compounds into promising drug candidates. Herein, docking and molecular dynamics simulations were employed in order to understand
Externí odkaz:
https://doaj.org/article/a9490e75ad504a6f8e96b3812d86805b