Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Desiree H.H. Tsao"'
Autor:
Steve Tam, Qin Wang, Adrian Huang, Desiree H.H. Tsao, Natalia Sushkova, Michael Dennis Lowe, Gray D. Shaw, Patricia W. Bedard, Li Di, Boris Tchernychev, James C. Keith, Neelu Kaila, Robert G. Schaub, Kristin Janz, Valerie Clerin, Alessandro Moretto
Publikováno v:
Journal of Medicinal Chemistry. 53:6003-6017
Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tole
Autor:
Desiree H.H. Tsao, Arthur Lee, Lori Krim Gavrin, Franklin J. Moy, Zhang Bao Xu, John C. McKew, Lidia Mosyak, Elizabeth Kieras, Wayne Stochaj, Annette Sievers
Publikováno v:
Journal of Medicinal Chemistry. 53:1238-1249
To aid in the pursuit of selective kinase inhibitors, we have developed a unique ATP site binder tool for the detection of binders outside the ATP site by nuclear magnetic resonance (NMR). We report here the novel synthesis that led to this paramagne
Autor:
Raymond T. Camphausen, Cheryl Nickerson-Nutter, Desiree H.H. Tsao, Neelu Kaila, Adam D. Shilling, Ruth Young-Sciame, Silvano DeBernardo, Patricia W. Bedard, Kristin Janz, Qin Wang, Tam Steve Yik-Kai, James C. Keith
Publikováno v:
Journal of Medicinal Chemistry. 50:21-39
Leukocyte recruitment of sites of inflammation and tissue injury involves leukocyte rolling along the endothelial wall, followed by firm adherence of the leukocyte, and finally transmigration of the leukocyte across cell junctions into the underlying
Autor:
Karen L. Wheless, Desiree H.H. Tsao, Weidong Ding, Juan C. Alvarez, Alexey Ruzin, Kenneth Foreman, Alan G. Sutherland, Pornpen Labthavikul, Lidia Mosyak, Thomas S. Rush, Peter Petersen, Cynthia Hess Kenny
Publikováno v:
Org. Biomol. Chem.. 1:4138-4140
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhib
Autor:
Desiree H.H. Tsao, Alessandro Mascioni, Franklin J. Moy, Viktoria Gusarova, Shuo Lin, Deborah A. Dilts, Scott Sigethy, Karl Malakian, Lisa K. McNeil, Pamela S. Fink, Ellen Murphy, Gary W. Zlotnick, Susan K. Hoiseth, Elena G. Novikova, Breagh E. Bentley, Mininni Terri L, Rosaria Camarda
Publikováno v:
Biochimica et biophysica acta. 1798(2)
Neisseria meningitidis is a major cause of meningitis. Although protective vaccination is available against some pathogenic serogroups, serogroup B meningococci have been a challenge for vaccinologists. A family of outer membrane lipoproteins, LP2086
Autor:
James C. Keith, Valerie Clerin, Desiree H.H. Tsao, Patricia W. Bedard, Silvano DeBernardo, Tam Steve Yik-Kai, Kristin Janz, Alessandro Moretto, Raymond T. Camphausen, Gray D. Shaw, Robert G. Schaub, Qin Wang, Adrian Huang, Natalia Sushkova, Neelu Kaila
Publikováno v:
Journal of medicinal chemistry. 50(1)
P-selectin-PSGL-1 interaction causes rolling of leukocytes on the endothelial cell surface, which subsequently leads to firm adherence and leukocyte transmigration through the vessel wall into the surrounding tissues. P-selectin is upregulated on the
Autor:
Yuanhong Li, Cynthia Hess Kenny, Desiree H.H. Tsao, A. Karl Malakian, Russell Dushin, Ramaswamy Nilakantan, Weidong Ding, Elizabeth G. Dushin, Alan G. Sutherland, Lidia Mosyak, Lee D. Jennings, Thomas S. Rush, Juan C. Alvarez, Steve A. Haney
Publikováno v:
Bioorganicmedicinal chemistry. 14(23)
ZipA is a membrane anchored protein in Escherichia coli that interacts with FtsZ, a homolog of eukaryotic tubulins, forming a septal ring structure that mediates bacterial cell division. Thus, the ZipA/FtsZ protein-protein interaction is a potential
Autor:
Alexey Ruzin, Peter Petersen, Lidia Mosyak, Mohani N. Sukhdeo, Thomas S. Rush, Margareta Tuckman, Lee D. Jennings, Elizabeth G. Dushin, Soraya L. Moghazeh, Alan G. Sutherland, Yuanhong Li, Ken W. Foreman, Cynthia Hess Kenny, Desiree H.H. Tsao, Weidong Ding
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(6)
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ
Autor:
Steven A. Haney, Soraya L. Moghazeh, Thomas S. Rush, Pornpen Labthavikul, Margareta Tuckman, Peter Petersen, Lidia Mosyak, Lee D. Jennings, Mohani N. Sukhdeo, Weidong Ding, Alexey Ruzin, Hanlan Liu, Desiree H.H. Tsao, Scott L. Kincaid, Alan G. Sutherland, Cynthia Hess Kenny, Elizabeth G. Dushin, Chantel L. Sabus, Kenneth Foreman
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5884
Autor:
Joe Zhongxiang Zhou
Publikováno v:
Methods in Molecular Biology ISBN: 9781607619307
Chemical Library Design
Chemical Library Design
Part I: General Topics 1. Historical Overview of Chemical Library Design Roland E. Dolle 2. Chemoinformatics and Library Design Joe Zhongxiang Zhou 3. Molecular Library Design Using Multi-Objective Optimization Methods Christos A Nicolaou and Christo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15a39c5515814c8b97738c25786b648
https://doi.org/10.1007/978-1-60761-931-4
https://doi.org/10.1007/978-1-60761-931-4