Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Desiree Antequera"'
Autor:
Macarena de la Cueva, Desiree Antequera, Lara Ordoñez‑Gutierrez, Francisco Wandosell, Antonio Camins, Eva Carro, Fernando Bartolome
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c5ea4e6af79f456c8b9034534676f791
Autor:
Macarena de la Cueva, Desiree Antequera, Lara Ordoñez-Gutierrez, Francisco Wandosell, Antonio Camins, Eva Carro, Fernando Bartolome
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The most accepted hypothesis in Alzheimer’s disease (AD) is the amyloid cascade which establishes that Aβ accumulation may induce the disease development. This accumulation may occur years before the clinical symptoms but it has not been
Externí odkaz:
https://doaj.org/article/c4c788ab38e24e9e93f36d32dcaf83ea
Autor:
Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins, Eva Carro
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulates energy homeostasis
Externí odkaz:
https://doaj.org/article/b6d91bb541cb4cc3ae593efacfeebc38
Autor:
Desiree Antequera, Diego Moneo, Laura Carrero, Fernando Bartolome, Isidro Ferrer, Gordon Proctor, Eva Carro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In the last few years, microbial infection and innate immune theories have been proposed as an alternative approach explaining the etiopathogenesis and origin of Alzheimer’s disease (AD). Lactoferrin, one of the main antimicrobial proteins in saliv
Externí odkaz:
https://doaj.org/article/8930d42536224165a53ee10ce32fd053
Autor:
Desiree Antequera, Laura Carrero, Victoria Cunha Alves, Isidro Ferrer, Jesús Hernández-Gallego, Cristina Municio, Eva Carro
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1645 (2022)
Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer’s disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-β clearance, but it is known to be
Externí odkaz:
https://doaj.org/article/4c595590315d42ad95a594f6c8857d47
Autor:
Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez, Eva Carro
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood–brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an
Externí odkaz:
https://doaj.org/article/ce1ff3b247b74aee8a25c73c982e1f23
Autor:
Marta González-Sánchez, Javier Jiménez, Arantzazu Narváez, Desiree Antequera, Sara Llamas-Velasco, Alejandro Herrero-San Martín, Jose Antonio Molina Arjona, Adolfo López de Munain, Alberto Lleó Bisa, M.-Pilar Marco, Montserrat Rodríguez-Núñez, David Andrés Pérez-Martínez, Alberto Villarejo-Galende, Fernando Bartolome, Elena Domínguez, Eva Carro
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 571 (2020)
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is consid
Externí odkaz:
https://doaj.org/article/405350ab088d471c83af58a3ed0faadf
Autor:
Desiree Antequera, Marta Bolos, Carlos Spuch, Consuelo Pascual, Isidro Ferrer, María Isabel Fernandez-Bachiller, María Isabel Rodríguez-Franco, Eva Carro
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 3, Pp 682-691 (2012)
Several studies have implicated the enzyme acetylcholinesterase (AChE) as well as several biometals in the pathogenesis of Alzheimer's disease (AD). A multifunctional molecule, the hybrid tacrine-8-hydroxyquinoline (named IQM-622), displays cholinerg
Externí odkaz:
https://doaj.org/article/79769aecea2b47098a743438a7c73ac5
Autor:
Desiree Antequera, Teo Vargas, Cristina Ugalde, Carlos Spuch, Jose Antonio Molina, Isidro Ferrer, Felix Bermejo-Pareja, Eva Carro
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 1, Pp 42-50 (2009)
Accumulation of amyloid-β (Aβ) peptides is thought to be a critical event in the pathology of Alzheimer's disease (AD), because they induce multiple neurotoxic effects, including mitochondrial dysfunction and apoptotic cell death. Therefore the red
Externí odkaz:
https://doaj.org/article/a0852fd1680544348156924c56454c19
Autor:
Eduardo Anitua, Consuelo Pascual, Rocio Pérez-Gonzalez, Desiree Antequera, Sabino Padilla, Gorka Orive, Eva Carro
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73118 (2013)
Neurodegeneration together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration of these was assessed with div
Externí odkaz:
https://doaj.org/article/1ba31aaaa83145c68abc9f0c11fd0dfa