Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Desiree A. Thayer"'
Autor:
Matthew Bratkowski, Tian Xie, Desiree A. Thayer, Shradha Lad, Prakhyat Mathur, Yu-San Yang, Gregory Danko, Thomas C. Burdett, Jean Danao, Aaron Cantor, Jennifer A. Kozak, Sean P. Brown, Xiaochen Bai, Shilpa Sambashivan
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107999- (2020)
Summary: The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) a
Externí odkaz:
https://doaj.org/article/313bc7f0c8174c0b846a7e9facf8f63c
Publikováno v:
The Journal of Physiology. 594:6701-6713
Studies in cultured hippocampal neurons and the COS-7 cell line demonstrate important roles for N-linked glycosylation of Kv1.2 channels in forward trafficking and protein degradation. Kv1.2 channels can contain complex N-linked glycans, which facili
Autor:
Xiao Chen Bai, Desiree A. Thayer, Shilpa Sambashivan, Jean Danao, Tian Xie, Jennifer A. Kozak, Matthew Bratkowski, Prakhyat Mathur, Thomas C. Burdett, Sean P. Brown, Gregory Danko, Aaron Cantor, Shradha Lad, Yu San Yang
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107999-(2020)
Summary The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 A) and active SARM1 (6.8 A) and
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 4
The Golgi complex is essential for many aspects of cellular function, including trafficking and sorting of membrane and secretory proteins and posttranslational modification by glycosylation. We observed reversible fragmentation of the Golgi complex
Autor:
Chi-Huey Wong, Desiree A. Thayer
Publikováno v:
Chemistry – An Asian Journal. 1:445-452
Many natural products contain carbohydrate moieties that contribute to their biological activity. Manipulation of the carbohydrate domain of natural products through multiple glycosylations to identify new derivatives with novel biological activities
Autor:
Michael D. Best, Cheng-Yuan Huang, Julia Hoffmann, Desiree A. Thayer, Chi-Huey Wong, Aileen Y. Chang, Steve Head
Publikováno v:
Proceedings of the National Academy of Sciences. 103:15-20
Understanding the specificity of cell-surface carbohydrates interaction with antibodies and receptors is important for the development of new therapeutics and high-sensitivity diagnostics. This approach is, however, limited to the availability of nat
Publikováno v:
Angewandte Chemie. 117:4672-4675
Autor:
Chun Han, Lily Yeh Jan, Desiree A. Thayer, Marjolaine Noirclerc-Savoye, Céline Lafaye, Dan Yu, Antoine Royant, Thomas B. Kornberg, Xiaokun Shu, Yuh Nung Jan, William A. Weiss, Woo Ping Ge, Hai Huang, William Clay Gustafson
Publikováno v:
Shu, Xiaokun; Jan, Lily; Jan, Yuh; Gustafson, William; Yu, D; Gustafson, WC; et al.(2014). An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7vj3k500
Nature communications
Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5, pp.3626
Nature Communications, 2014, 5, pp.3626
Nature communications
Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5, pp.3626
Nature Communications, 2014, 5, pp.3626
International audience; Infrared fluorescent proteins (IFPs) are ideal for in vivo imaging, and monomeric versions of these proteins can be advantageous as protein tags or for sensor development. In contrast to GFP, which requires only molecular oxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650bdfcbe8cf4f02c0ccae10ee05b474
http://www.escholarship.org/uc/item/7vj3k500
http://www.escholarship.org/uc/item/7vj3k500
Autor:
Desiree A, Thayer, Lily Y, Jan
Publikováno v:
Current opinion in drug discoverydevelopment. 13(5)
The discovery and development of pharmaceutical drugs targeting ion channels is important for treating a variety of medical conditions and diseases. Ion channels are expressed ubiquitously throughout the body, and are involved in many basic physiolog
Publikováno v:
Chemical communications (Cambridge, England). (25)
We report the design, synthesis, membrane activity, biophysical characterization, and in vitro antibacterial activities of cationic cyclic d,l-α-glycopeptides bearing side chains derivatized with d-glucosamine (GlcNH2), d-galactose (Gal), or d-manno