Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions.

Autor: Pringle ES; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Duguay BA; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Bui-Marinos MP; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.; Snyder Institute for Chronic Diseases and Charbonneau Institute of Cancer Research, University of Calgary, Calgary, Canada., Mulloy RP; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.; Snyder Institute for Chronic Diseases and Charbonneau Institute of Cancer Research, University of Calgary, Calgary, Canada., Landreth SL; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.; Vaccine and Infectious Disease Organization (VIDO), Saskatoon, Canada., Desireddy KS; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada., Dolliver SM; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Ying S; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Caddell T; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Tooley TH; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Slaine PD; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., Bearne SL; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.; Department of Chemistry, Dalhousie University, Halifax, Canada., Falzarano D; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.; Vaccine and Infectious Disease Organization (VIDO), Saskatoon, Canada., Corcoran JA; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.; Snyder Institute for Chronic Diseases and Charbonneau Institute of Cancer Research, University of Calgary, Calgary, Canada., Khaperskyy DA; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada., McCormick C; Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Sep 19; Vol. 18 (9), pp. e1010832. Date of Electronic Publication: 2022 Sep 19 (Print Publication: 2022).