Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Desireé Kaufmann"'
Autor:
Gabriele M. König, Alesia A. Tietze, Desireé Kaufmann, Raphael Reher, Daniel Tietze, Felix Hausch, Andreas M. Voll
Publikováno v:
Journal of Chemical Information and Modeling. 59:4361-4373
Specific inhibition of G proteins holds a great pharmacological promise to, e.g., target oncogenic Gq/11 proteins and can be achieved by the two natural products FR900359 (FR) and YM-254890 (YM). Unfortunately, recent rational-design-based approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbfb93f4ec22775df34b89235e69beb
https://doi.org/10.1021/acs.jcim.9b00433
https://doi.org/10.1021/acs.jcim.9b00433
Autor:
Charlotte A. Bäuml, Evi Kostenis, Daniel Tietze, Tobias Benkel, Desireé Kaufmann, Max Crüsemann, Toni Kühl, Stefan Kehraus, Raphael Reher, Justin Patrick Odhiambo, Britta Nubbemeyer, Suvi Annala, Diana Imhof, Gabriele M. König, Pascal Heimer
Publikováno v:
ChemMedChem. 13:1634-1643
Direct targeting of intracellular Gα subunits of G protein-coupled receptors by chemical tools is a challenging task in current pharmacological studies and in the development of novel therapeutic approaches. In this study we analyzed novel FR900359-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05eccf1f87ce43469c8c7aa866a539f1
https://doi.org/10.1002/cmdc.201800304
https://doi.org/10.1002/cmdc.201800304
Autor:
Raphael, Reher, Toni, Kühl, Suvi, Annala, Tobias, Benkel, Desireé, Kaufmann, Britta, Nubbemeyer, Justin Patrick, Odhiambo, Pascal, Heimer, Charlotte Anneke, Bäuml, Stefan, Kehraus, Max, Crüsemann, Evi, Kostenis, Daniel, Tietze, Gabriele M, König, Diana, Imhof
Publikováno v:
ChemMedChem. 13(16)
Direct targeting of intracellular Gα subunits of G protein-coupled receptors by chemical tools is a challenging task in current pharmacological studies and in the development of novel therapeutic approaches. In this study we analyzed novel FR900359-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad5b2c25cadac7732a1092426f0a5678
https://pubmed.ncbi.nlm.nih.gov/29873888
https://pubmed.ncbi.nlm.nih.gov/29873888
Autor:
Suvi Annala, Charlotte A. Bäuml, Justin Patrick Odhiambo, Toni Kühl, Diana Imhof, Max Crüsemann, Gabriele M. König, Raphael Reher, Pascal Heimer, Britta Nubbemeyer, Daniel Tietze, Tobias Benkel, Evi Kostenis, Stefan Kehraus, Desireé Kaufmann
Publikováno v:
ChemMedChem. 13:1617-1617
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7977a15d42fcbe184910e1cec13f644e
https://doi.org/10.1002/cmdc.201800521
https://doi.org/10.1002/cmdc.201800521
Autor:
Ajay Abisheck Paul George, Pascal Heimer, Enrico Leipold, Thomas Schmitz, Desiree Kaufmann, Daniel Tietze, Stefan H. Heinemann, Diana Imhof
Publikováno v:
Marine Drugs, Vol 17, Iss 7, p 390 (2019)
Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel NaV1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simulations bas
Externí odkaz:
https://doaj.org/article/32742123ecf1403585f3326f2a9638c7
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 180 (2019)
Understanding subtype specific ion channel pore blockage by natural peptide-based toxins is crucial for developing such compounds into promising drug candidates. Herein, docking and molecular dynamics simulations were employed in order to understand
Externí odkaz:
https://doaj.org/article/a9490e75ad504a6f8e96b3812d86805b