Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Desheng, Lu"'
Autor:
Mengfang Yan, Zijie Su, Xiaoyi Pang, Hanbin Wang, Han Dai, Jiong Ning, Shanshan Liu, Qi Sun, Jiaxing Song, Xibao Zhao, Desheng Lu
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2277-2297 (2024)
Casein kinase 1ε (CK1ε) and axis inhibitor 1 (AXIN1) are crucial components of the β‐catenin destruction complex in canonical Wnt signaling. CK1ε has been shown to interact with AXIN1, but its physiological function and role in tumorigenesis re
Externí odkaz:
https://doaj.org/article/f7d4e374ffa04ddc88efd2b791dc294b
Autor:
Zhen Liu, Qilin Zhou, Liangge He, Zhengdong Liao, Yajing Cha, Hongyu Zhao, Wenchao Zheng, Desheng Lu, Sheng Yang
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Premature ovarian failure (POF) is a clinical condition characterized by the cessation of ovarian function, leading to infertility. The underlying molecular mechanisms remain unclear, and no predictable biomarkers have been identi
Externí odkaz:
https://doaj.org/article/1a7e313f9d2940169084d63a9d7f4958
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism
Autor:
Xin Zhang, Yajun Duan, Su Li, Zhenyuan Zhang, Linyuan Peng, Xiaoyu Ma, Tianzhi Wang, Siliang Xiang, Guo Chen, Danyang Zhou, Desheng Lu, Minxian Qian, Zhongyuan Wang
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114662- (2024)
Summary: Ferroptosis is a form of nonapoptotic cell death characterized by iron-dependent peroxidation of polyunsaturated phospholipids. However, much remains unknown about the regulators of ferroptosis. Here, using CRISPR-Cas9-mediated genetic scree
Externí odkaz:
https://doaj.org/article/432c5b3f912d4d2f841128c064ba7330
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
BackgroundFamily socioeconomic status (FSES) serves as a significant determinant for subjective well-being. However, extant research has provided conflicting evidence on the correlation between FSES and adolescent students’ subjective well-being (S
Externí odkaz:
https://doaj.org/article/6bac04027e9d48b89262ae78c6d3776b
Autor:
Lifeng Tan, Mengfang Yan, Zijie Su, Hanbin Wang, Huan Li, Xibao Zhao, Shanshan Liu, Long Zhang, Qi Sun, Desheng Lu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract R-spondins (RSPOs) are secreted signaling molecules that potentiate the Wnt/β-catenin pathway by cooperating with Wnt ligands. RSPO1 is crucial in tissue development and tissue homeostasis. However, the molecular mechanism by which RSPOs ac
Externí odkaz:
https://doaj.org/article/d8b517d8e7034ad99dda22ae52694beb
Autor:
Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang, Su Li, Kai Wang, Mei Yang, Xiaoyu Ma, Danlan Zhang, Siliang Xiang, Yajun Duan, Tianzhi Wang, Chunmeng Sun, Chen Wang, Desheng Lu, Minxian Qian, Zhongyuan Wang
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114003- (2024)
Summary: The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway is
Externí odkaz:
https://doaj.org/article/5115bbac385b4c26b93bf2fb64d54e93
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27162- (2024)
Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) experience a significant occurrence rate and are susceptible to premature spreading, resulting in a bleak outlook. Therapeutic approaches, such as chemotherapy, targeted therapy
Externí odkaz:
https://doaj.org/article/9f392153d986472b861fee0e6552b99d
Autor:
Vivian Weiwen Xue, Shanshan Liu, Qi Sun, Jiong Ning, Huan Li, Weilan Wang, Sapna Sayed, Xibao Zhao, Li Fu, Desheng Lu
Publikováno v:
Translational Oncology, Vol 40, Iss , Pp 101863- (2024)
Introduction: Autophagy is an important mechanism of cell homeostasis maintenance. As essential serine/threonine-protein kinases, casein kinase I family members affect tumorigenesis by regulating a variety of cellular progression. However, the mechan
Externí odkaz:
https://doaj.org/article/84ddf43e50cc4354bc4a77f11e7b70e1
Autor:
Sapna Sayed, Mehdihasan Shekh, Jiaxing Song, Qi Sun, Han Dai, Vivian Weiwen Xue, Shanshan Liu, Bing Du, Guangqian Zhou, Florian J. Stadler, Guangming Zhu, Desheng Lu
Publikováno v:
Materials Today Bio, Vol 23, Iss , Pp 100849- (2023)
There is a high demand for an optimal drug delivery system to treat androgenetic alopecia. Topical application of ISX9, which is a neurogenesis inducer, has been found to stimulate hair follicle (HF) regrowth by upregulating the Wnt/β-catenin signal
Externí odkaz:
https://doaj.org/article/8860a9bfddc54b7da1afbd3af9d94c3b
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background The kinesin-13 family member 2C (KIF2C) is a versatile protein participating in many biological processes. KIF2C is frequently up-regulated in multiple types of cancer and is associated with cancer development. However, the role o
Externí odkaz:
https://doaj.org/article/c748ae84961942b29e440c87a5aa976e