Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Desethermuscarine"'
Autor:
Carlo Melchiorre
Publikováno v:
Synthetic Communications. 6:125-128
Recently we reported the synthesis of desether-muscarine,1 a compound of interesting cholinergic activity. The starting material for this synthesis was the 3-methyl-3-cyclopentene-l-carboxylic acid (II) already synthesized through photochemical addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39fbe41dbd281311dd260f1467def43f
https://doi.org/10.1080/00397917608072621
https://doi.org/10.1080/00397917608072621
Publikováno v:
Synthetic Communications. 5:95-100
We have recently reported the synthesis of allo- and epi-dese-thermuscarine from 4t-methyl- and 4c-methyl-3c-hydroxy-1r-(N, N, -di-methylcarboxamido) cyclopentane, (II) and (III) respectively. Although this stereospecific synthetic route is simple in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef37becfeb3aa6c222a6d5ce70357897
https://doi.org/10.1080/00397917508061438
https://doi.org/10.1080/00397917508061438
Publikováno v:
Synthetic Communications. 6:63-68
Recently, the synthesis of desethermuscarine 1-3 and of two of its three possible isomers, allo– and epi– desethermuscarine, 4,5 was reported. These substances, having muscarinic activity, have shown to be extremely interesting in the study of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f1b5ec12966fc68eb7179031227c94
https://doi.org/10.1080/00397917608072610
https://doi.org/10.1080/00397917608072610
Publikováno v:
Journal of Medicinal Chemistry. 17:457-459
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37da73bf940c6a37c60dae11eef7e529
https://doi.org/10.1021/jm00250a020
https://doi.org/10.1021/jm00250a020
Publikováno v:
Chemischer Informationsdienst. 8
The synthesis of epiallo-desethermuscarine (I) is reported. Its pharmacological activity has been tested and compared with the other carbocyclic analogs of muscarine and its derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c697a17f66f2906eb24fa2fb1fb5e2d4
https://doi.org/10.1002/chin.197727166
https://doi.org/10.1002/chin.197727166
Autor:
Pigini M, Giannella M, Gamba G, Carlo Melchiorre, Gualtieri F, Pigini P, Cingolani Ml, Rossini L
Publikováno v:
Chemischer Informationsdienst. 6
Two new methods of syntesis of (+/-)-desethermuscarine (I) are reported along with the pharmacological evaluation of (I) extended to several muscarinic and nicotinic receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55af464df599ee15f3161859502e1b57
https://doi.org/10.1002/chin.197532195
https://doi.org/10.1002/chin.197532195
Publikováno v:
Chemischer Informationsdienst. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a8d3890cdabb1830e49cab74071ead
https://doi.org/10.1002/chin.197436166
https://doi.org/10.1002/chin.197436166
Autor:
Pigini P, Rossini L, L. Re, Pigini M, Carlo Melchiorre, Gamba G, Cingolani Ml, Gualtieri F, Giannella M
Publikováno v:
Chemischer Informationsdienst. 7
Some substances similar to desethermuscarine were synthesized and studied as cholinergics on isolated organs. The results show the importance of the cyclopentane nucleus with regard to activity. The activity of 3-methyltrimethylammonium hexane iodide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4569b0cbf59c1fb2c967c074015c32c1
https://doi.org/10.1002/chin.197626170
https://doi.org/10.1002/chin.197626170