Zobrazeno 1 - 10
of 1 580
pro vyhledávání: '"Desensitization (telecommunications)"'
Autor:
Stefan O. Ciurea, Piyanuch Kongtim, Gabriela Rondon, Salman Otoukesh, Stephen J. Forman, Richard E. Champlin, Julianne Chen, Auayporn Nademanee, Michiko Taniguchi, Kai Cao, Ketevan Gendzekhadze, Fleur M. Aung, Jun Zou, Monzr M. Al Malki
Publikováno v:
Blood Advances. 5:4031-4043
Donor-specific anti-HLA antibodies (DSAs) are a major cause of engraftment failure in patients receiving haploidentical stem cell transplantation (HaploSCT). Effective treatments are needed for these patients, who often have no other donor options an
Autor:
Qiqi Zhou, Hang Qi, Yi-Quan Tang, Jiajie Luo, Yanru Zhang, Xiaowen Tang, Wei Zhu, KeWei Wang, Zhengji Yin, Zhen Qiao, Ningning Wei
Publikováno v:
Journal of Medicinal Chemistry. 64:16282-16292
Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated in sensing noxious stimuli and nociceptive signaling. However, small-molecule tools
Autor:
Sandra Bandleon, Paula Anahi Arias-Loza, Antonella Cellini, Dorina Höfler, Christoph Maack, Wolfgang R. Bauer, Petra Eder-Negrin, Tanja Langsenlehner, Michael Kohlhaas
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H650-H662
Reduced systolic and diastolic calcium levels in cardiomyocytes from NKA-α2 transgenic mice minimize the desensitization of the β-adrenergic signaling system. These effects result in an improved β-adrenergic reserve and prevent functional deterior
Autor:
Bridget M. Crawford, Tuan Vo-Dinh, Fang Yuan, Zhen-Ming Pei, Mengyun Wang, Yuan Chi, Zhonghao Jiang, Chao Wang, Feifei Huang, Fei-Hua Wu, Di Wan
Publikováno v:
Plant, Cell & Environment. 44:3793-3805
The flagellin epitope flg22, a pathogen-associated molecular pattern (PAMP), binds to the receptor-like kinase FLAGELLIN SENSING2 (FLS2), and triggers Ca2+ influx across the plasma membrane (PM). The flg22-induced increases in cytosolic Ca2+ concentr
Autor:
Jeremy M. Yeung, Jeffrey B. Lo, Sheung Pun Tsai, Granger G.C. Hwa, Jeffrey A. Roberts, Phillip C. Allen
Publikováno v:
Journal of Medical Primatology. 50:291-298
BACKGROUND Capsaicin is used in several areas of non-human primate research including allodynia and dermal blood flow (DBF). The capsaicin-induced DBF increase was measured using laser Doppler imaging (LDI), but this response is known to diminish upo
Autor:
Yingye Fang, Thomas P. Burris, Antonina I. Frolova, P. I. Imoukhuede, Sarah K. England, Michael D. Ward, Thomas Koelblen, Gregory R. Bowman, Maxwell I. Zimmerman, Justin R. Porter, Manasi Malik, Michelle Roh
Publikováno v:
ACS Pharmacology & Translational Science. 4:1543-1555
The hormone oxytocin is commonly administered during childbirth to initiate and strengthen uterine contractions and prevent postpartum hemorrhage. However, patients have wide variation in the oxytocin dose required for a clinical response. To begin t
Autor:
Shuichi Katsuki, Naoya Hatano, Masumi Eto, Toshio Kitazawa, Kai Akagi, Kosuke Takeya, Akira Goto, Hiroshi Tokumitsu, Toshiyasu Matsui
Publikováno v:
American Journal of Physiology-Cell Physiology. 321:C549-C558
Cell signaling pathways regulating myosin regulatory light chain (LC20) phosphorylation contribute to determining contractile responses in smooth muscles. Following excitation and contraction, phasic smooth muscles, such as the digestive tract and ur
Autor:
Daichi Morii, Ako Hanaoka, Daijiro Kabata, Toshihide Naganuma, Junji Uchida, Yoshiaki Takemoto, Ayumi Shintani
Publikováno v:
Blood Purification. 50(6):829-836
Introduction: In patients requiring both hemodialysis (HD) and apheresis, the 2 treatments can be performed simultaneously. At our hospital, selective plasma exchange (SePE) is often performed along with HD for removal of isoagglutinins before ABO-in
Publikováno v:
Neuroscience and Behavioral Physiology. 51:784-792
The aims of the present work were: a) to study the contribution of glucocorticoid hormones to gastroprotection induced by sensitization of capsaicin-sensitive afferent neurons (CSN); b) to study the gastroprotective effect of corticotropin-releasing
Publikováno v:
Annals of Laboratory Medicine
Pretransplant crossmatch (XM) testing is widely used for detecting preformed donor-specific antibodies (DSAs) against human leukocyte antigen (HLA). However, in some cases, there is a positive XM result in the absence of HLA-DSAs, the cause of which