A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice.

Autor: Woodcock IR; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Tachas G; Antisense Therapeutics Ltd, Melbourne, Australia., Desem N; Antisense Therapeutics Ltd, Melbourne, Australia., Houweling PJ; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Kean M; Department of Medical Imaging, The Royal Children's Hospital, Melbourne, Australia., Emmanuel J; Department of Medical Imaging, The Royal Children's Hospital, Melbourne, Australia., Kennedy R; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Physiotherapy, University of Melbourne, Melbourne, Australia., Carroll K; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia., de Valle K; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Physiotherapy, University of Melbourne, Melbourne, Australia., Adams J; The Murdoch Children's Research Institute, Melbourne, Australia., Lamandé SR; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Coles C; The Murdoch Children's Research Institute, Melbourne, Australia., Tiong C; The Murdoch Children's Research Institute, Melbourne, Australia., Burton M; The Murdoch Children's Research Institute, Melbourne, Australia., Villano D; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia., Button P; McCloud Consulting Group, Sydney, Australia., Hogrel JY; Institut de Myologie, GH Pitié-Salpêtrière, Paris, France., Catling-Seyffer S; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia., Ryan MM; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Delatycki MB; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Bruce Lefroy Centre for Genetic Health Research, Melbourne, Australia., Yiu EM; Department of Neurology, The Royal Children's Hospital, Melbourne, Australia.; The Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Publikováno v: PloS one [PLoS One] 2024 Jan 25; Vol. 19 (1), pp. e0294847. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024).

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: A randomised, double-blind, placebo-controlled phase 2 clinical trial

Autor: Rice, ASC, Dworkin, RH, McCarthy, TD, Anand, P, Bountra, C, McCloud, PI, Hill, J, Cutter, G, Kitson, G, Desem, N, Raff, M

Publikováno v: The Lancet. 383(9929)

Summary Background Existing treatments for postherpetic neuralgia, and for neuropathic pain in general, are limited by modest efficacy and unfavourable side-effects. The angiotensin II type 2 receptor (AT 2 R) is a new target for neuropathic pain. EM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0171229a7cbeabe4db08dc4d7cd73730
http://ora.ox.ac.uk/objects/uuid:5314ad38-f149-48a7-ae58-1bf6fd744fb3

CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS.

Autor: Limmroth V; From the Department of Neurology (V.L.), Cologne City Hospitals, University of Cologne, Germany; the Department of Radiology (F.B.), VU Medical Centre, Amsterdam, the Netherlands; and Antisense Therapeutics Ltd. (N.D., M.P.D., G.T.), Melbourne, Australia., Barkhof F; From the Department of Neurology (V.L.), Cologne City Hospitals, University of Cologne, Germany; the Department of Radiology (F.B.), VU Medical Centre, Amsterdam, the Netherlands; and Antisense Therapeutics Ltd. (N.D., M.P.D., G.T.), Melbourne, Australia., Desem N; From the Department of Neurology (V.L.), Cologne City Hospitals, University of Cologne, Germany; the Department of Radiology (F.B.), VU Medical Centre, Amsterdam, the Netherlands; and Antisense Therapeutics Ltd. (N.D., M.P.D., G.T.), Melbourne, Australia., Diamond MP; From the Department of Neurology (V.L.), Cologne City Hospitals, University of Cologne, Germany; the Department of Radiology (F.B.), VU Medical Centre, Amsterdam, the Netherlands; and Antisense Therapeutics Ltd. (N.D., M.P.D., G.T.), Melbourne, Australia., Tachas G; From the Department of Neurology (V.L.), Cologne City Hospitals, University of Cologne, Germany; the Department of Radiology (F.B.), VU Medical Centre, Amsterdam, the Netherlands; and Antisense Therapeutics Ltd. (N.D., M.P.D., G.T.), Melbourne, Australia. george.tachas@antisense.com.au.

Publikováno v: Neurology [Neurology] 2014 Nov 11; Vol. 83 (20), pp. 1780-8. Date of Electronic Publication: 2014 Sep 19.

Exploring Extended White Blood Cell Parameters for the Evaluation of Sepsis among Patients Admitted to Intensive Care Units.

Autor: Ho, Sook Fong^1,2 (AUTHOR) hsf_sookfong@yahoo.com, Tan, Swee Jin³ (AUTHOR) lee.yingxian@sysmex.com.my, Mazlan, Mohd Zulfakar⁴ (AUTHOR) zulfakar@usm.my, Iberahim, Salfarina^1,2 (AUTHOR) salfarina@usm.my, Lee, Ying Xian³ (AUTHOR), Hassan, Rosline^1,2 (AUTHOR) tan.sweejin@sysmex-ap.com

Publikováno v: Diagnostics (2075-4418). Jul2023, Vol. 13 Issue 14, p2445. 11p.

Frequent detection of IFN-gamma-producing memory effector and effector T cells in patients with progressive multifocal leukoencephalopathy.

Autor: de Goër de Herve, Marie-Ghislaine, Dekeyser, Manon, Hendel-Chavez, Houria, Maillart, Elisabeth, Labeyrie, Céline, Adams, David, Moreau, Thibault, Lubetzki, Catherine, Papeix, Caroline, Stankoff, Bruno, Gasnault, Jacques, Taoufik, Yassine

Publikováno v: Frontiers in Immunology; 2024, p1-9, 9p