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27MO Integrated digital pathology and single-cell analysis identify the spatial and temporal evolution of immune cells networks in epithelial ovarian cancer

Autor: Ghisoni, E., Benedetti, F., Cunnea, P., Fahr, N., Gulhan, D.C., Minasyan, A., Desbuisson, M., Grimm, A., Barras, D., Dagher, J., Fortis, E., Rusakiewicz, S., Tissot, S., Mastroyannis, S.A., Swisher, E., Kandalaft, L., Tanyi, J., Fotopoulou, C., Coukos, G., Dangaj, D.

Publikováno v: In Annals of Oncology June 2022 33 Supplement 5:S395-S395

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.

Autor: Bruand M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Barras D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Mina M; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland., Ghisoni E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Morotti M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Lanitis E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Fahr N; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Desbuisson M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Grimm A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Zhang H; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China., Chong C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Dagher J; Institute of Pathology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Chee S; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA., Tsianou T; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Dorier J; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Bioinformatics Competence Center, University of Lausanne, Lausanne, Switzerland., Stevenson BJ; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Iseli C; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ronet C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Bobisse S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Genolet R; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Walton J; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK., Bassani-Sternberg M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Kandalaft LE; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Ren B; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA., McNeish I; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK., Swisher E; Department of Oncology, Washington University, Seattle, WA, USA., Harari A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Delorenzi M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ciriello G; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland., Irving M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Rusakiewicz S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Foukas PG; 2nd Department of Pathology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece., Martinon F; Department of Biochemistry, UNIL, Lausanne, Switzerland., Dangaj Laniti D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: denarda.dangaj@chuv.ch., Coukos G; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: george.coukos@chuv.ch.

Publikováno v: Cell reports [Cell Rep] 2021 Jul 20; Vol. 36 (3), pp. 109412.