Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Des C, Jones"'
Autor:
Simon Dovedi, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Becki Dudley, Marcin Wolny, Seraina Blümli, Ellie Chatzopoulou, Alan Sandercock, Stacy Pryts
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/27c1e65ddcfa42aa9c4332c72d2c1022
Autor:
Muchaala Yeboah, Charys Papagregoriou, Des C. Jones, H.T. Claude Chan, Guangan Hu, Justine S. McPartlan, Torbjörn Schiött, Ulrika Mattson, C. Ian Mockridge, Ulla-Carin Tornberg, Björn Hambe, Anne Ljungars, Mikael Mattsson, Ivo Tews, Martin J. Glennie, Stephen M. Thirdborough, John Trowsdale, Björn Frendeus, Jianzhu Chen, Mark S. Cragg, Ali Roghanian
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Despite advances in identifying the key immunoregulatory roles of many of the human leukocyte immunoglobulin-like receptor (LILR) family members, the function of the inhibitory molecule LILRB3 (ILT5, CD85a, LIR3) remains unclear. Studies indicate a p
Externí odkaz:
https://doaj.org/article/90cb438ae1ab42bbb9e4805195e6e841
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Table 1Suppl. Table 1 related to materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c867539694432660b7dd69219ed965
https://doi.org/10.1158/2326-6066.22544859.v1
https://doi.org/10.1158/2326-6066.22544859.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Figures S1-S7Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cee7b46fd70653a2fd06bbbb1e9efe
https://doi.org/10.1158/2326-6066.22544862.v1
https://doi.org/10.1158/2326-6066.22544862.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec9ec374bbda9dffe535a040c2c2b71
https://doi.org/10.1158/2326-6066.c.6550767.v1
https://doi.org/10.1158/2326-6066.c.6550767.v1
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
Supplementary Materials and Methods, and Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037
https://doi.org/10.1158/2159-8290.22540037
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263
https://doi.org/10.1158/2159-8290.c.6549263
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Autor:
Lapaque, Nicolas, Hutchinson, James L., Des C. Jones, Méresse, Stéphane, Holden, David W., Trowsdale, John, Kelly, Adrian P., Cresswell, Peter
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2009 Aug . 106(33), 14052-14057.
Externí odkaz:
https://www.jstor.org/stable/40484365
Autor:
Madhu Ramaswamy, Taeil Kim, Des C. Jones, Hormas Ghadially, Tamer I. Mahmoud, Andrew Garcia, Gareth Browne, Zenon Zenonos, Yvonne Puplampu-Dove, Jeffrey M. Riggs, Geetha K. Bhat, Ronald Herbst, Darren J. Schofield, Gianluca Carlesso
Publikováno v:
Cancer immunology research. 10(2)
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece