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The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model

Autor: Derya Bocuk, Alexander Wolff, Petra Krause, Gabriela Salinas, Annalen Bleckmann, Christina Hackl, Tim Beissbarth, Sarah Koenig

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-15 (2017)

Abstract Background Colorectal cancer (CRC) is the second leading cause of cancer-related death in men and women. Systemic disease with metastatic spread to distant sites such as the liver reduces the survival rate considerably. The aim of this study

Externí odkaz: https://doaj.org/article/013dcd4c0472480d8a88b5a849124eb6

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Authors’ reply to Schaffalitzky de Muckadell and colleague’s Comment on 'Evaluation of the Reported Rates of Severe Hypersensitivity Reactions Associated with Ferric Carboxymaltose and Iron (III) Isomaltoside 1000 in Europe Based on Data from EudraVigilance and VigiBase™ between 2014 and 2017'

Autor: Derya Bocuk, Stefan Wohlfeil, Massoud Toussi, Birgit Ehlken, Annegret Gohlke, Lennart Nathell

Publikováno v: Drug Safety. 42:693-696

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5e6a7c350b5be743b978d04d17c6cf
https://doi.org/10.1007/s40264-019-00815-4

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Evaluation of the Reported Rates of Severe Hypersensitivity Reactions Associated with Ferric Carboxymaltose and Iron (III) Isomaltoside 1000 in Europe Based on Data from EudraVigilance and VigiBase™ between 2014 and 2017

Autor: Annegret Gohlke, Stefan Wohlfeil, Massoud Toussi, Birgit Ehlken, Lennart Nathell, Derya Bocuk

Publikováno v: Drug Safety

Introduction Hypersensitivity reactions (HSRs) are among the known adverse events of intravenous (i.v.) iron products. Of these, particularly severe HSRs such as anaphylaxis are of great clinical concern due to their life-threatening potential. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca624f9293ffd656ca38eba8c5ac19
https://doi.org/10.1007/s40264-018-0769-5

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Misdirection of endosomal trafficking mediated by herpes simplex virus–encoded glycoprotein B

Autor: Sebastian Temme, Norbert Koch, Derya Bocuk, Thorsten Lang, Oddmund Bakke, Tone F. Gregers, Anna Maria Eis-Hübinger, Angelique Ziegfeld, Naima Niazy, Carmen A. Giesen, Nadine Temme, Angelika König

Publikováno v: The FASEB Journal. 31:1650-1667

Herpes simplex virus (HSV)-encoded glycoprotein B (gB) is the most abundant protein in the viral envelope and promotes fusion of the virus with the cellular membrane. In the present study, we found that gB impacts on the major histocompatibility comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55913e3bf1cea8c8fe17484909f8c551
https://doi.org/10.1096/fj.201600521r

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The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway

Autor: Sarah Koenig, Florian Klemm, Derya Bocuk, Petra Krause, Robin Stelling, Tobias Pukrop, Malte B. Monin, Sabine Niebert

Publikováno v: Journal of Surgical Research. 203:193-205

Background Wnt/β-catenin signaling is known to play an important role in colorectal cancer (CRC). Niclosamide, a salicylamide derivative used in the treatment of tapeworm infections, targets the Wnt/β-catenin pathway. The objective of this study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300f9f2949b16d9a23f97c938dcc7c60
https://doi.org/10.1016/j.jss.2016.03.051

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