Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Derun Zheng"'
Autor:
Jiabing Li, Shujun Xiao, Fangfang Shi, Huaxin Song, Jiaqi Wu, Derun Zheng, Xueqin Chen, Kai Tan, Min Lu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-11 (2023)
Abstract Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. It is a severe cancer predisposition syndrome with a poor prognosis, partly due to the frequent development of subsequent prim
Externí odkaz:
https://doaj.org/article/dbe6d5fcd29a4cf0a7e60b6f55f3f4ce
Autor:
Huaxin Song, Jiale Wu, Yigang Tang, Yuting Dai, Xinrong Xiang, Ya Li, Lili Wu, Jiaqi Wu, Ying Liang, Yangfei Xing, Ni Yan, Yuntong Li, Zhengyuan Wang, Shujun Xiao, Jiabing Li, Derun Zheng, Xinjie Chen, Hai Fang, Chenjing Ye, Yuting Ma, Yu Wu, Wen Wu, Junming Li, Sujiang Zhang, Min Lu
Publikováno v:
Science Translational Medicine. 15
Tumor suppressor p53 is inactivated by thousands of heterogeneous mutations in cancer, but their individual druggability remains largely elusive. Here, we evaluated 800 common p53 mutants for their rescue potencies by the representative generic rescu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df77f46fd8b6433453ee0ed271ff6d7
https://doi.org/10.1126/scitranslmed.abn9155
https://doi.org/10.1126/scitranslmed.abn9155
Autor:
Yigang Tang, Huaxin Song, Zhengyuan Wang, Shujun Xiao, Xinrong Xiang, Huien Zhan, Lili Wu, Jiale Wu, Yangfei Xing, Yun Tan, Ying Liang, Ni Yan, Yuntong Li, Jiabing Li, Jiaqi Wu, Derun Zheng, Yunchuan Jia, Zhiming Chen, Yunqi Li, Qianqian Zhang, Jianming Zhang, Hui Zeng, Wei Tao, Feng Liu, Yu Wu, Min Lu
Publikováno v:
Cell reports. 39(2)
The tumor suppressor p53 is inactivated by over hundreds of heterogenous mutations in cancer. Here, we purposefully selected phenotypically reversible temperature-sensitive (TS) p53 mutations for pharmacological rescue with thermostability as the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482bc3a6377279326f2534a8ead535bb
https://pubmed.ncbi.nlm.nih.gov/35417717
https://pubmed.ncbi.nlm.nih.gov/35417717