Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Derrick Watkins"'
Autor:
Derrick Watkins, Dev Arya
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Hfq is required by many Gram-negative bacteria to chaperone the interaction between small non-coding RNA (sRNA) and mRNA to facilitate annealing. Conversely and despite the presence of Hfq in many Gram-positive bacteria, sRNAs in Gram-positive bacter
Externí odkaz:
https://doaj.org/article/3edc3af99bfa4a5080ecb43b7c78ecd9
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144251 (2015)
MicroRNAs (miRNA) are small RNAs that have a regulatory role in gene expression. Because of this regulatory role, miRNAs have become a new target for therapeutic compounds. Here, we outline an approach to target specific miRNAs using a high throughpu
Externí odkaz:
https://doaj.org/article/549f97dd5b19407498148a1b84e8c306
Autor:
Shreyas S Athavale, Anton S Petrov, Chiaolong Hsiao, Derrick Watkins, Caitlin D Prickett, J Jared Gossett, Lively Lie, Jessica C Bowman, Eric O'Neill, Chad R Bernier, Nicholas V Hud, Roger M Wartell, Stephen C Harvey, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38024 (2012)
Mg²⁺ shares a distinctive relationship with RNA, playing important and specific roles in the folding and function of essentially all large RNAs. Here we use theory and experiment to evaluate Fe²⁺ in the absence of free oxygen as a replacement f
Externí odkaz:
https://doaj.org/article/68414350f7b84ae5b7fba11e7849ef2a
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1973
Aminoglycoside functionalization as a tool for targeting natural and unnatural nucleic acids holds great promise in their development as diagnostic probes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly
Publikováno v:
Methods in Molecular Biology ISBN: 9781493992157
Aminoglycoside functionalization as a tool for targeting natural and unnatural nucleic acids holds great promise in their development as diagnostic probes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401d7b3848ded1576a106f1ae335e1d9
https://doi.org/10.1007/978-1-4939-9216-4_9
https://doi.org/10.1007/978-1-4939-9216-4_9
Autor:
Arren Z. Washington, Ada King, Derrick Watkins, Keith D. Green, Sylvie Garneau-Tsodikova, Yi Jin, Changjun Gong, Liuwei Jiang, Adegboyega K. Oyelere, Dev P. Arya
Publikováno v:
ACS Chemical Biology. 10:1278-1289
A 215-member mono- and diamino acid peptidic-aminosugar (PA) library, with neomycin as the model aminosugar, was systematically and rapidly synthesized via solid phase synthesis. Antibacterial activities of the PA library, on 13 bacterial strains (se
Autor:
Dev P. Arya, Derrick Watkins
Publikováno v:
Non-coding RNA Investigation. 3:28-28
Small non-coding RNAs continue to be identified that regulate the processes of translation and transcription in prokaryotes. A variety of regulatory mechanisms have been characterized by these regulatory RNAs that occur by complementary base pairing
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5689-5693
Synthesis of a novel class of compounds and their biophysical studies with TAR-RNA are presented. The synthesis of these compounds was achieved by conjugating neomycin, an aminoglycoside, with benzimidazoles modeled from a B-DNA minor groove binder,
Publikováno v:
Bioorganicmedicinal chemistry. 25(4)
Nucleic acids adopt a broad array of hydrogen-bonded structures that enable their diverse roles in the cell; even the familiar DNA double helix displays subtle architectural nuances that are sequence dependent. While there have been many approaches f
Recognition of RNA by high-affinity binding small molecules is crucial for expanding existing approaches in RNA recognition, and for the development of novel RNA binding drugs. A novel neomycin dimer benzimidazole conjugate 5 (DPA 83) was synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38ae076c0b53529b6852fac4a0375b2
https://europepmc.org/articles/PMC4837457/
https://europepmc.org/articles/PMC4837457/