Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Derrick Theys"'
Autor:
Melissa C. Southey, James G. Dowty, Moeen Riaz, Jason A. Steen, Anne-Laure Renault, Katherine Tucker, Judy Kirk, Paul James, Ingrid Winship, Nicholas Pachter, Nicola Poplawski, Scott Grist, Daniel J. Park, Bernard J. Pope, Khalid Mahmood, Fleur Hammet, Maryam Mahmoodi, Helen Tsimiklis, Derrick Theys, Amanda Rewse, Amanda Willis, April Morrow, Catherine Speechly, Rebecca Harris, Robert Sebra, Eric Schadt, Paul Lacaze, John J. McNeil, Graham G. Giles, Roger L. Milne, John L. Hopper, Tú Nguyen-Dumont
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing are urgently required. Most prior research has been based on women selected for high-risk features and more data is needed
Externí odkaz:
https://doaj.org/article/e1da7e8351b04cec94eb8ba4ee5e1962
Autor:
Pierre-Antoine Dugué, Chenglong Yu, Timothy McKay, Ee Ming Wong, Jihoon Eric Joo, Helen Tsimiklis, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, kConFab, John L. Hopper, Graham G. Giles, Roger L. Milne, Jason A. Steen, James G. Dowty, Tu Nguyen-Dumont, Melissa C. Southey
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2535 (2021)
VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associated with disease including risk and progression of cancer. This study investigated the influence of genetic variation an
Externí odkaz:
https://doaj.org/article/c495a9a5a0b448a6acd3955cdd873132
Autor:
Derrick Theys, Melissa C. Southey, Maryam Mahmoodi, Fleur Hammet, Tu Nguyen-Dumont, Graham G. Giles, Daniel J. Park, Helen Tsimiklis, John L. Hopper, Bernard J. Pope, Mark Clendenning, Jason A. Steen, Ingrid Winship
Publikováno v:
Familial Cancer. 19:197-202
The advent of gene panel testing is challenging the previous practice of using clinically defined cancer family syndromes to inform single-gene genetic screening. Individual and family cancer histories that would have previously indicated testing of
Autor:
Melissa C. Southey, Fleur Hammet, Timothy McKay, Chenglong Yu, Maryam Mahmoodi, Jihoon E. Joo, Roger L. Milne, Jason A. Steen, John L. Hopper, Tu Nguyen-Dumont, Helen Tsimiklis, Derrick Theys, kConFab, Graham G. Giles, James G. Dowty, Ee Ming Wong, Pierre Antoine Dugué
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2535, p 2535 (2021)
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2535, p 2535 (2021)
VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associated with disease including risk and progression of cancer. This study investigated the influence of genetic variation an
Autor:
Maryam Mahmoodi, Roger L. Milne, Derrick Theys, Tu Nguyen-Dumont, Fleur Hammet, Melissa C. Southey, Graham G. Giles, James G. Dowty, Amanda Rewse, John L. Hopper, Helen Tsimiklis, Ingrid Winship, Anne-Laure Renault, Jason A. Steen
Publikováno v:
Cancers, Vol 13, Iss 1378, p 1378 (2021)
Cancers
Volume 13
Issue 6
Cancers
Volume 13
Issue 6
551 Background: Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein truncating variant CHEK2c.1100
Autor:
Tú, Nguyen-Dumont, James G, Dowty, Jason A, Steen, Anne-Laure, Renault, Fleur, Hammet, Maryam, Mahmoodi, Derrick, Theys, Amanda, Rewse, Helen, Tsimiklis, Ingrid M, Winship, Graham G, Giles, Roger L, Milne, John L, Hopper, Melissa C, Southey
Publikováno v:
Cancers
Simple Summary It is well established that women who carry pathogenic CHEK2 variants have about a 3-fold increased risk of developing breast cancer. CHEK2 is now commonly included in genetic tests for breast cancer predisposition and increasingly use
Autor:
Pierre Antoine Dugué, Moeen Riaz, Graham G. Giles, James G. Dowty, Helen Tsimiklis, Melissa C. Southey, Damien M Bolton, Eric E. Schadt, Roger L. Milne, Maryam Mahmoodi, Fleur Hammet, Gianluca Severi, Tu Nguyen-Dumont, Anne-Laure Renault, Derrick Theys, Robert Sebra, John J McNeil, Robert J. MacInnis, Jason A. Steen, Paul Lacaze
Publikováno v:
Cancers
Cancers, 2021, 13 (7), pp.1495. ⟨10.3390/cancers13071495⟩
Volume 13
Issue 7
Cancers, MDPI, 2021, 13 (7), ⟨10.3390/cancers13071495⟩
Cancers, Vol 13, Iss 1495, p 1495 (2021)
Cancers, 2021, 13 (7), pp.1495. ⟨10.3390/cancers13071495⟩
Volume 13
Issue 7
Cancers, MDPI, 2021, 13 (7), ⟨10.3390/cancers13071495⟩
Cancers, Vol 13, Iss 1495, p 1495 (2021)
While gene panel sequencing is becoming widely used for cancer risk prediction, its clinical utility with respect to predicting aggressive prostate cancer (PrCa) is limited by our current understanding of the genetic risk factors associated with pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cb56b1e6f20838a9235b279c63fa3d
https://hal.archives-ouvertes.fr/hal-03199072/document
https://hal.archives-ouvertes.fr/hal-03199072/document
Autor:
Tu, Nguyen-Dumont, Pawel, Karpinski, Maria M, Sasiadek, Hayane, Akopyan, Jason A, Steen, Derrick, Theys, Fleur, Hammet, Helen, Tsimiklis, Daniel J, Park, Bernard J, Pope, Ryszard, Slezak, Agnieszka, Stembalska, Karolina, Pesz, Nataliya, Kitsera, Aleksandra, Siekierzynska, Melissa C, Southey, Aleksander, Myszka
Publikováno v:
Genetics Research
Purpose To characterize the spectrum of BRCA1 and BRCA2 pathogenic germline variants in women from south-west Poland and west Ukraine affected with breast or ovarian cancer. Testing in women at high risk of breast and ovarian cancer in these regions
Autor:
Aleksandra Siekierzynska, Ryszard Slezak, Melissa C. Southey, Daniel J. Park, Agnieszka Stembalska, Maria M. Sasiadek, Nataliya Kitsera, Helen Tsimiklis, Derrick Theys, Fleur Hammet, Pawel Karpinski, Jason A. Steen, Tu Nguyen-Dumont, Karolina Pesz, Aleksander Myszka, Hayane Akopyan, Bernard J. Pope
Publikováno v:
Genetics Research. 102
Purpose To characterize the spectrum of BRCA1 and BRCA2 pathogenic germline variants in women from south-west Poland and west Ukraine affected with breast or ovarian cancer. Testing in women at high risk of breast and ovarian cancer in these regions
Autor:
Derrick Theys, Melissa C. Southey, Gianluca Severi, Helen Tsimiklis, Fleur Hammet, Daniel J. Park, Tu Nguyen-Dumont, Damien M Bolton, Roger L. Milne, Maryam Mahmoodi, Bernard J. Pope, Jason A. Steen, Khalid Mahmood, Robert J. MacInnis, Graham G. Giles
Publikováno v:
International journal of cancerREFERENCES. 147(8)
Few genetic risk factors have been demonstrated to be specifically associated with aggressive prostate cancer (PrCa). Here, we report a case-case study of PrCa comparing the prevalence of germline pathogenic/likely pathogenic (P/LP) genetic variants