Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Derrick R Hicks"'
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, T. J. Brunette, Derrick R. Hicks, Tomos E. Morgan, Tim J. Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature. 616:581-589
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in is
Autor:
Stacey R Gerben, Andrew J Borst, Derrick R Hicks, Isabelle Moczygemba, David Feldman, Brian Coventry, Wei Yang, Asim K. Bera, Marcos Miranda, Alex Kang, Hannah Nguyen, David Baker
Publikováno v:
Biochemistry. 62:358-368
Autor:
Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Ali Etemadi, Seong An, Andrew Favor, Devon Ehnes, Zhe Li, Florian Praetorius, Max Gordon, Wei Yang, Brian Coventry, Derrick R Hicks, Longxing Cao, Neville Bethel, Piper Heine, Analisa N Murray, Stacey Gerben, Lauren Carter, Marcos Miranda, Babak Negahdari, Sangwon Lee, Cole Trapnell, Lance Stewart, Damian C Ekiert, Joseph Schlessinger, Jay Shendure, Gira Bhabha, Hannele Ruohola-Baker, David Baker
Publikováno v:
bioRxiv
Growth factors and cytokines signal by binding to the extracellular domains of their receptors and drive association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling cascades. To enable s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabf19b52c9e40ae334b69d4789b7567
https://europepmc.org/articles/PMC10055045/
https://europepmc.org/articles/PMC10055045/
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, TJ Brunette, Derrick R. Hicks, Tomos E Morgan, Tim J Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian Ekiert, David Baker
General approaches for designing sequence-specific peptide binding proteins would have wide utility in proteomics and synthetic biology. Although considerable progress has been made in designing proteins which bind to other proteins, the general pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7fff23e15bdae13920e1136bfa6c20
https://doi.org/10.1101/2022.11.14.514089
https://doi.org/10.1101/2022.11.14.514089
Autor:
Linna An, Derrick R Hicks, Dmitri Zorine, Justas Dauparas, Basile I. M. Wicky, Lukas F. Milles, Alexis Courbet, Asim K. Bera, Hannah Nguyen, Alex Kang, Lauren Carter, David Baker
In pseudocyclic proteins such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving rise to a central cavity which can serve as a pocket for ligand binding or enzymatic activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fa9895ece579b995a6f26482e5c841
https://doi.org/10.1101/2022.09.01.506251
https://doi.org/10.1101/2022.09.01.506251
Autor:
Derrick R. Hicks, Madison A. Kennedy, Kirsten A. Thompson, Michelle DeWitt, Brian Coventry, Alex Kang, Asim K. Bera, T. J. Brunette, Banumathi Sankaran, Barry Stoddard, David Baker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
Function follows form in biology, and the binding of small molecules requires proteins with pockets that match the shape of the ligand. For design of binding to symmetric ligands, protein homo-oligomers with matching symmetry are advantageous as each
Autor:
Merika Treants Koday, Christopher D. Bahl, Aaron Chevalier, Lu Zhang, Lauren Carter, James T. Fuller, Deborah H. Fuller, Gabriel J. Rocklin, Inna Goreshnik, Min Dong, Kwok-Ho Lam, Shin-Ichiro Miyashita, David Baker, Steffen M. Bernard, Tom Colvin, Rongsheng Jin, Cassie M. Bryan, Guorui Yao, Xuhui Huang, Renan Vergara, Ian A. Wilson, Derrick R. Hicks, Lance Stewart, Cody M. Jenkins, D. Alejandro Fernández-Velasco, Daniel-Adriano Silva, Patience Murapa, Alan J. Bohn
Publikováno v:
Nature, vol 550, iss 7674
De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-s
Autor:
Derrick R. Hicks, Justin M. Kollman, Zemer Gitai, Rachael M. Barry, Allison Maker, Eric M. Lynch, Matthew Shepherd, Jesse M Hansen, Enoch P. Baldwin, James A. Endrizzi
Publikováno v:
Lynch, EM; Hicks, DR; Shepherd, M; Endrizzi, JA; Maker, A; Hansen, JM; et al.(2017). Human CTP synthase filament structure reveals the active enzyme conformation. Nature Structural and Molecular Biology, 24(6), 507-514. doi: 10.1038/nsmb.3407. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3rw467w9
Nature structural & molecular biology, vol 24, iss 6
Nature structural & molecular biology
Nature structural & molecular biology, vol 24, iss 6
Nature structural & molecular biology
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and eukaryotes. In bacteria, polymerization inhibits CTPS activity and is required for nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f29f0ff7e6956afee6916bca377022e
http://www.escholarship.org/uc/item/3rw467w9
http://www.escholarship.org/uc/item/3rw467w9
Autor:
Chang-Quan Wang, Geoffrey Benn, Katayoon Dehesh, Jeffrey Stein, Derrick R. Hicks, Cade Guthrie
Publikováno v:
The Plant Journal. 80:82-92
Plants cope with environmental challenges by rapidly triggering and synchronizing mechanisms governing stress-specific and general stress response (GSR) networks. The GSR acts rapidly and transiently in response to various stresses, but the underpinn
Autor:
Federica Brandizzi, Bpantamars Phadungchob, Derrick R. Hicks, Venkat Apparao Kolla, John E. Froehlich, Zainab Nasafi, Wassim E. Chehab, Katayoon Dehesh, Chang-Quan Wang, Tatyana Savchenko
Publikováno v:
Plant Physiology. 164:1151-1160
Membranes are primary sites of perception of environmental stimuli. Polyunsaturated fatty acids are major structural constituents of membranes that also function as modulators of a multitude of signal transduction pathways evoked by environmental sti