Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Derrick John Bowen"'
Publikováno v:
Haematologica, Vol 92, Iss 2 (2007)
The cysteine allele of the amino acid polymorphism (AAP) Y/C1584 in the A2 domain of von Willebrand factor (VWF) has been shown to correlate with enhanced VWF proteolysis by ADAMTS13. The frequencies and effect on VWF proteolysis of six reported AAP
Externí odkaz:
https://doaj.org/article/5403319ce2ca4d058e45cb6d06fdfc5b
Publikováno v:
Molecular Immunology. 52:88-95
The C5a receptor (C5aR) is a 7 transmembrane G-protein coupled receptor (GPCR) that mediates the powerful pro-inflammatory effect of the complement activation product C5a. Excess C5a generated under pathological conditions has been implicated in a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d09fe4b55315726324e47fdafa0421
https://doi.org/10.1016/j.molimm.2012.04.012
https://doi.org/10.1016/j.molimm.2012.04.012
Autor:
A. M. Cumming, M. Bowman, Stephen Keeney, Charles R. M. Hay, Megan Sutherland, Andrew M. Will, Derrick John Bowen, Peter William Collins, Paula H. B. Bolton-Maggs
Publikováno v:
Blood. 114:1091-1098
Direct sequencing of VWF genomic DNA in 21 patients with type 3 von Willebrand disease (VWD) failed to reveal a causative homozygous or compound heterozygous VWF genotype in 5 cases. Subsequent analysis of VWF mRNA led to the discovery of a deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087bb2e657c641a0bf4cdfa7fc41542f
https://doi.org/10.1182/blood-2008-08-173278
https://doi.org/10.1182/blood-2008-08-173278
Publikováno v:
Haemophilia. 14:1099-1111
von Willebrand disease (VWD) is a common autosomally inherited bleeding disorder associated with mucosal or trauma-related bleeding in affected individuals. VWD results from a quantitative or qualitative deficiency of von Willebrand factor (VWF), a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6d0400fd78bda2d1f9dcc50817f248
https://doi.org/10.1111/j.1365-2516.2008.01813.x
https://doi.org/10.1111/j.1365-2516.2008.01813.x
Autor:
Jeanne Kingston, Mark Worwood, Susan Lawless, Helen A. Jackson, Derrick John Bowen, Marion Carol Sweeney
Publikováno v:
Journal of Clinical Pathology. 60:1244-1248
Objective: To describe the analysis of over 5300 patient samples for the HFE genotype. Methods: Blood samples received from hospitals in England, Wales and Ireland were analysed with a single, multiplex PCR using heteroduplex generators for the C282Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7735d6be7337ee776307490eedc7ea3
https://doi.org/10.1136/jcp.2006.042010
https://doi.org/10.1136/jcp.2006.042010
Publikováno v:
British Journal of Haematology. 133:457-467
The proteolysis of von Willebrand factor (VWF) by the recently discovered metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin repeats), is a normal processing step in VWF biochemistry. Emerging data indicate that this step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1436d169abe02cac2a9ec85ece9b5e
https://doi.org/10.1111/j.1365-2141.2006.06096.x
https://doi.org/10.1111/j.1365-2141.2006.06096.x
Autor:
M. A. Haj, Derrick John Bowen, H. I. Sati, Peter William Collins, N. Murch, A. Benton, A. Beddal
Publikováno v:
European Journal of Haematology. 76:440-443
Acquired von Willebrand syndrome (AvWS) is a relatively rare bleeding disorder. It has been reported in association with myeloproliferative disorders, autoimmune diseases, plasma cell dyscrasias and certain drugs. Cefotaxime is a third generation cep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edcf9385243ea4d3b74a3b27ee32501
https://doi.org/10.1111/j.0902-4441.2006.t01-1-ejh2386.x
https://doi.org/10.1111/j.0902-4441.2006.t01-1-ejh2386.x
Autor:
Charles R. M. Hay, Frank Hill, Andrea Guilliatt, Peter William Collins, Pamela Grundy, William Lester, Derrick John Bowen, A. M. Cumming, Stephen Keeney, Said Enayat, John Pasi, Paula H B Bolton-Maggs, David Keeling
Publikováno v:
Thrombosis and Haemostasis. 96:630-641
SummaryForty families diagnosed by UK centres to have type 1 VWD were recruited. Following review, six families were re-diagnosed to have type 2 VWD, one to have a platelet storage pool disorder, and one family was determined to be unaffected. Direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fb43623c88217b1da3de19baf9c78c
https://doi.org/10.1160/th06-07-0383
https://doi.org/10.1160/th06-07-0383
Autor:
R. Campbell Tait, Will Lester, Jonathon T. Wilde, Derrick John Bowen, Frank Hill, Kate Khair, A. M. Cumming, K. John Pasi, Peter William Collins, Pamela Grundy, Paula H. B. Bolton-Maggs, Steven Keeney, David Keeling, Saad M. Enayat
Publikováno v:
British Journal of Haematology. 128:830-836
The molecular pathogenesis of type 1 von Willebrand disease (VWD) is uncertain in most patients. We examined 30 type 1 VWD families in the UK Haemophilia Centre Doctors' Organization study. Heterozygosity for Y/C1584 was present in eight of 30 (27%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0ce53ea386ad0e8235ea25ddec826b
https://doi.org/10.1111/j.1365-2141.2005.05375.x
https://doi.org/10.1111/j.1365-2141.2005.05375.x
Publikováno v:
British Journal of Haematology. 126:602-605
We describe a multiplex polymerase chain reaction (PCR)-based test that detected all relevant NRAS activating mutations using a single PCR followed directly by electrophoresis. The test uses a Universal Heteroduplex Generator (UHG) to detect exon-2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151f996b88c327e7b473999e7b3cd259
https://doi.org/10.1111/j.1365-2141.2004.05079.x
https://doi.org/10.1111/j.1365-2141.2004.05079.x