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pro vyhledávání: '"Derrick Jing Yang Tan"'
Publikováno v:
Nucleic Acids Research
The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex–duple
Publikováno v:
Chemical communications (Cambridge, England). 57(45)
Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily coup