Human cytomegalovirus transcriptome activity differs during replication in human fibroblast, epithelial and astrocyte cell lines

Autor: James C. Towler, Derrick J. Dargan, Bahram Ebrahimi, Brian Lane, Andrew J. Davison

Publikováno v: The Journal of General Virology

Broad cell tropism contributes to the pathogenesis of human cytomegalovirus (HCMV), but the extent to which cell type influences HCMV gene expression is unclear. A bespoke HCMV DNA microarray was used to monitor the transcriptome activity of the low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc2afa4c74bd88cd796f4e05d90f178
http://europepmc.org/articles/PMC3541802

Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens

Autor: Andrew J. Davison, Katarina Baluchova, Birgitta Hilfrich, Derrick J. Dargan, Paul D. Griffiths, Derek Gatherer, Thomas F. Schulz, Gavin William Grahame Wilkinson, Charles Cunningham, Marian Thomson

Publikováno v: Cunningham, C, Gatherer, D, Hilfrich, B, Baluchova, K, Dargan, D J, Thomson, M, Griffith, P D, Wilkinson, G W G, Schulz, T F & Davison, A J 2010, ' Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens ', Journal of General Virology, vol. 91, pp. 605-615 . https://doi.org/10.1099/vir.0.015891-0
The Journal of General Virology

We have assessed two approaches to sequencing complete human cytomegalovirus (HCMV) genomes (236 kbp) in DNA extracted from infected cell cultures (strains 3157, HAN13, HAN20 and HAN38) or clinical specimens (strains JP and 3301). The first approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133a83e1313aa1cda5e04ec474bcbb40
https://doi.org/10.1099/vir.0.015891-0

Genetic content of wild-type human cytomegalovirus

Autor: Derrick J. Dargan, Clare Addison, Vincent C. Emery, Andrew J. Davison, Charles Cunningham, Aycan F. Hassan-Walker, Lydia Lee, Derek Gatherer, Duncan J. McGeoch, Aidan Dolan, Ralph D. Hector, Gavin William Grahame Wilkinson, Brian P. McSharry, Paul D. Griffiths, Christian Sinzger

Publikováno v: Journal of General Virology. 85:1301-1312

The genetic content of wild-type human cytomegalovirus was investigated by sequencing the 235 645 bp genome of a low passage strain (Merlin). Substantial regions of the genome (genes RL1–UL11, UL105–UL112 and UL120–UL150) were also sequenced in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d50df606826becef022690292770f0
https://doi.org/10.1099/vir.0.79888-0

Fundamental and accessory systems in herpesviruses

Autor: Nigel D. Stow, Derrick J. Dargan, Andrew J. Davison

Publikováno v: Antiviral Research. 56:1-11

Evolutionary studies have a large theoretical component and will not directly provide therapies for herpesvirus infections. However, they do provide a conceptual framework within which we can evaluate the origins of the various systems that contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c86608dc14193fe52a671f56727004
https://doi.org/10.1016/s0166-3542(02)00107-9

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Autor: Derrick J. Dargan, John H. Subak-Sharpe

Publikováno v: Virus Genes. 16:239-251

Comparison of the herpes simplex virus type 1 (HSV-1) DNA sequence with that of other α, β and γ-herpesviruses, allied with molecular genetic studies have greatly increased understanding of the HSV genome and the functions encoded by individual vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be8698e671bad856959c6ef3d335fa8
https://doi.org/10.1023/a:1008068902673