Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Derrick E. Rancourt"'
Autor:
Breanna S. Borys, Tiffany Dang, Hannah Worden, Leila Larijani, Jessica M. Corpuz, Brett D. Abraham, Emilie J. Gysel, Julia Malinovska, Roman Krawetz, Tamas Revay, Bob Argiropoulos, Derrick E. Rancourt, Michael S. Kallos, Sunghoon Jung
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of
Externí odkaz:
https://doaj.org/article/2db8d01dfcf348088a43dc9d70f85a86
Autor:
Suman C. Nath, Shahnaz Babaei-Abraki, Guoliang Meng, Kali A. Heale, Charlie Y. M. Hsu, Derrick E. Rancourt
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Enzymatic dissociation of human pluripotent stem cells (hPSCs) into single cells during routine passage leads to massive cell death. Although the Rho-associated protein kinase inhibitor, Y-27632 can enhance hPSC survival and proliferation at
Externí odkaz:
https://doaj.org/article/ccfb54411f4f4308a0016601fd064c9d
Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury
Autor:
Leah Ferrie, Priyatha Premnath, Alexandra Olsen, Leila Larijani, Bryce A. Besler, Derrick E. Rancourt, Neil A. Duncan, T. Michael Underhill, Roman J. Krawetz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment methods. There has been significant research on the use of stem cells with and wi
Externí odkaz:
https://doaj.org/article/5e9c50e958ae434a8e717179d078fa47
Autor:
Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee, Michael S. Kallos
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has bee
Externí odkaz:
https://doaj.org/article/2bc815c68c614342b30ff70eac6b8561
Autor:
Breanna S. Borys, Tania So, James Colter, Tiffany Dang, Erin L. Roberts, Tamas Revay, Leila Larijani, Roman Krawetz, Ian Lewis, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee, Michael S. Kallos
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 9, Pp 1036-1052 (2020)
Abstract Human induced pluripotent stem cells (hiPSCs) have generated a great deal of attention owing to their capacity for self‐renewal and differentiation into the three germ layers of the body. Their discovery has facilitated a new era in biomed
Externí odkaz:
https://doaj.org/article/12cda13c70c14445b8dbe352327b75a7
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Cell-based therapy (CBT) is attracting much attention to treat incurable diseases. In recent years, several clinical trials have been conducted using human pluripotent stem cells (hPSCs), and other potential therapeutic cells. Various private- and go
Externí odkaz:
https://doaj.org/article/9ae99faa1852444cb981838bc9d88a34
Autor:
Lijie Gao, Suman C. Nath, Xiyao Jiao, Rongyan Zhou, Sandra Nishikawa, Roman Krawetz, Xiangyun Li, Derrick E. Rancourt
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) are prone to anoikis after single cell dissociation. The small molecule, Y-27632 is known to increase survival of hESCs and hiPSCs by inhibiting the Rho-associated protein
Externí odkaz:
https://doaj.org/article/88b1631065ac4bb5956c9bb3e8d7704d
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 376-389 (2018)
Recent advances in stem cell biology have accelerated the pre-clinical development of cell-based therapies for degenerative and chronic diseases. The success of this growing area hinges upon the concomitant development of scalable manufacturing platf
Externí odkaz:
https://doaj.org/article/a9418b9e9e794e72bf8311647d6c8540
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5215 (2021)
Bone healing is a complex, well-organized process. Multiple factors regulate this process, including growth factors, hormones, cytokines, mechanical stimulation, and aging. One of the most important signaling pathways that affect bone healing is the
Externí odkaz:
https://doaj.org/article/36b1a1f9425145a594b9bb63c9e79518
Publikováno v:
Cells, Vol 9, Iss 1, p 191 (2020)
Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-different
Externí odkaz:
https://doaj.org/article/738d9be4fc164fef9c94847e28829d92