Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Derrick, Gibbings"'
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular tr
Externí odkaz:
https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349
Autor:
Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté, Derrick Gibbings
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate wi
Externí odkaz:
https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidifi
Externí odkaz:
https://doaj.org/article/ab7976e5b68445dbba7b4b920e534e98
Autor:
Wheaton Little, Charles Campbell, Daniel G. Anderson, Ryan Reshke, Piotr S. Kowalski, Luke H. Rhym, My Tran Trung, James A. Taylor, Derrick Gibbings, Alexandre Savard, Huishan Guo
Publikováno v:
Nature Biomedical Engineering. 4:52-68
A small percentage of the short interfering RNA (siRNA) delivered via passive lipid nanoparticles and other delivery vehicles reaches the cytoplasm of cells. The high doses of siRNA and delivery vehicle that are thus required to achieve therapeutic o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e9961722903992536769da4ace6564
https://doi.org/10.1038/s41551-019-0502-4
https://doi.org/10.1038/s41551-019-0502-4
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature communications, vol 13, iss 1
Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or “cancer-killing” viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68ee2ef0a895547c59e7429cd83a59b
https://pubmed.ncbi.nlm.nih.gov/35393414
https://pubmed.ncbi.nlm.nih.gov/35393414
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson’s disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048de2fa899f6a4c7bbc1933548190dd
http://link.springer.com/article/10.1186/s12974-019-1483-7
http://link.springer.com/article/10.1186/s12974-019-1483-7
Autor:
David Pépin, Raghav Mohan, Maisa Alkailani, Gareth Palidwor, Barbara C. Vanderhyden, Derrick Gibbings, Ariane Poulin
Publikováno v:
Nar Cancer
It is challenging to identify the causes and consequences of retrotransposon expression in human disease due to the hundreds of active genomic copies and their poor conservation across species. We profiled genomic insertions of retrotransposons in ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe5ed14e19b1a21faac2de20dbfbc66
https://pubmed.ncbi.nlm.nih.gov/33447827
https://pubmed.ncbi.nlm.nih.gov/33447827
Autor:
Matteo Da Ros, Harmeen Deol, Huishan Guo, Elizabeth M. Meiering, Alexandre Savard, Derrick Gibbings
Publikováno v:
Journal of neurochemistryREFERENCES. 156(4)
Many of the genes whose mutation causes Amyotrophic Lateral Sclerosis (ALS) are RNA-binding proteins which localize to stress granules, while others impact the assembly, stability, and elimination of stress granules. This has led to the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fdd4b625947880b5fda9566da1c497
https://pubmed.ncbi.nlm.nih.gov/32683701
https://pubmed.ncbi.nlm.nih.gov/32683701
Autor:
Emma Bondy-Chorney, Jocelyn Côté, Francesca A. Barry, Janice Robertson, Alexandre Savard, Julia Keith, Lorne Zinman, Véronique Tremblay, John Woulfe, Maneka Chitiprolu, Jean-François Couture, Mathieu Lavallée-Adam, Chantal Jagow, Gareth A. Palidwor, Ekaterina Rogaeva, Geneviève Paris, Derrick Gibbings
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Nature Communications
Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while ALS-linked mutations in other proteins impede elimination of stress granules. Repeat expansions in C9ORF72, the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96179302945c215a9d7a6e5ada31a7e
https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
Autor:
Nicholas D. LeBlond, Reham M. Alsaadi, Ryan Reshke, Truc T. Losier, Morgan D. Fullerton, Derrick Gibbings, Ryan C. Russell, Mercy Akuma, Zhihao Guo, Yujin Suk, Subash Sad, François-Xavier Campbell-Valois, Olivia C. McKee-Muir
Publikováno v:
Autophagy
Cell Reports, Vol 26, Iss 8, Pp 2150-2165.e5 (2019)
Cell Reports, Vol 26, Iss 8, Pp 2150-2165.e5 (2019)
Summary: The autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria. However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3bb2d62c336afbe92ae46c5a176731
https://pubmed.ncbi.nlm.nih.gov/31107135
https://pubmed.ncbi.nlm.nih.gov/31107135