Výsledky vyhledávání - "Derren J Heyes"

Akademický článek

Photocobilins integrate B12 and bilin photochemistry for enzyme control

Autor: Shaowei Zhang, Laura N. Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O. Johannissen, Lingyun Zhu, Matthew J. Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W. Levy, David Leys, Derren J. Heyes, Nigel S. Scrutton

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B12) can act as a light-sensing chromophore heralded a new field of B12-photobiology. Although mi

Externí odkaz: https://doaj.org/article/a0f44c530eda465fa74001ba20e7cc49

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Akademický článek

Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state.

Autor: Derren J Heyes, Basile Khara, Michiyo Sakuma, Samantha J O Hardman, Ronan O'Cualain, Stephen E J Rigby, Nigel S Scrutton

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52418 (2012)

Phytochromes are dimeric photoreceptors that regulate a range of responses in plants and microorganisms through interconversion of red light-absorbing (Pr) and far-red light-absorbing (Pfr) states. Photoconversion between these states is initiated by

Externí odkaz: https://doaj.org/article/99d246b991d7445c8e267b3477ac0c60

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Akademický článek

Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability.

Autor: Jacqueline Vieira, Alex R Jones, Antoine Danon, Michiyo Sakuma, Nathalie Hoang, David Robles, Shirley Tait, Derren J Heyes, Marie Picot, Taishi Yoshii, Charlotte Helfrich-Förster, Guillaume Soubigou, Jean-Yves Coppee, André Klarsfeld, Francois Rouyer, Nigel S Scrutton, Margaret Ahmad

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e31867 (2012)

Cryptochromes are conserved flavoprotein receptors found throughout the biological kingdom with diversified roles in plant development and entrainment of the circadian clock in animals. Light perception is proposed to occur through flavin radical for

Externí odkaz: https://doaj.org/article/8d5d8baa462448fba9b217d644b2480c

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Akademický článek

Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase.

Autor: Derren J Heyes, Samantha J O Hardman, David Mansell, John M Gardiner, Nigel S Scrutton

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45642 (2012)

The light-driven enzyme protochlorophyllide oxidoreductase (POR) catalyzes the reduction of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). This reaction is a key step in the biosynthesis of chlorophyll. Ultrafast photochemical processes wi

Externí odkaz: https://doaj.org/article/12bcd7e7cada49aca46cced3575354cc

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Akademický článek

Redox driven B12-ligand switch drives CarH photoresponse

Autor: Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J. Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O. Johannissen, Colin W. Levy, Laura N. Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schirò, Martin Weik, Nigel S. Scrutton, David Leys

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract CarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a seri

Externí odkaz: https://doaj.org/article/001606f7b0874be9a4255441eb03bd98

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Akademický článek

Quantum Biology: An Update and Perspective

Publikováno v: Quantum Reports, Vol 3, Iss 1, Pp 80-126 (2021)

Understanding the rules of life is one of the most important scientific endeavours and has revolutionised both biology and biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range of complex and dynamic biolo

Externí odkaz: https://doaj.org/article/c9a53bf8f9df40dfb0a9e770fea02dbf

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Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron–Electron Double Resonance Spectroscopy Study

Autor: Tobias M. Hedison, Andreea I. Iorgu, Donato Calabrese, Derren J. Heyes, Muralidharan Shanmugam, Nigel S. Scrutton

Publikováno v: Hedison, T M, Iorgu, A I, Calabrese, D, Heyes, D J, Shanmugam, M & Scrutton, N S 2022, ' Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron–Electron Double Resonance Spectroscopy Study ', The journal of physical chemistry letters, pp. 6927-6934 . https://doi.org/10.1021/acs.jpclett.2c01584

Copper nitrite reductases (CuNiRs) catalyze the reduction of nitrite to form nitric oxide. In recent years, new classes of redox partner linked CuNiRs have been isolated and characterized by crystallographic techniques. Solution-state biophysical stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce2ea17249a1a5481531892ed3eb160
https://research.manchester.ac.uk/en/publications/b1c27d29-3fe3-4ca5-9681-635a4ef7147d

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Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases

Autor: Samuel L. Rose, Seiki Baba, Hideo Okumura, Svetlana V. Antonyuk, Daisuke Sasaki, Tobias M. Hedison, Muralidharan Shanmugam, Derren J. Heyes, Nigel S. Scrutton, Takashi Kumasaka, Takehiko Tosha, Robert R. Eady, Masaki Yamamoto, S. Samar Hasnain

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(30)

Many enzymes utilize redox-coupled centers for performing catalysis where these centers are used to control and regulate the transfer of electrons required for catalysis, whose untimely delivery can lead to a state incapable of binding the substrate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caf10cd1217cfbe0b0123230e0bec71
https://pubmed.ncbi.nlm.nih.gov/35862453

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An unusual light-sensing function for coenzyme B

Autor: Harshwardhan, Poddar, Derren J, Heyes, Shaowei, Zhang, Samantha J, Hardman, Michiyo, Sakuma, Nigel S, Scrutton

Publikováno v: Methods in enzymology. 668

Coenzyme B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaead14010815a80519b9b575209a631
https://pubmed.ncbi.nlm.nih.gov/35589201

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A designed photoenzyme for enantioselective [2+2] cycloadditions

Autor: Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green

Publikováno v: Trimble, J, Crawshaw, R, Hardy, F, Levy, C, Brown, M J B, Fuerst, D E, Heyes, D, Obexer, R & Green, A 2022, ' A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions ', Nature., vol. 611, no. 7937 . https://doi.org/10.1038/s41586-022-05335-3

The ability to programme new modes of catalysis into proteins would allow the development of enzyme families with functions beyond those found in nature. To this end, genetic code expansion methodology holds particular promise, as it allows the site-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed299e8a23e39f23f13dd65b4bdded8
https://pubmed.ncbi.nlm.nih.gov/36130727

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