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Autor:
Alan R. McIntosh, Hui Helen Wang, Ke Qi, F. William Orr, Ruth J. Muschel, Abu-Bakr Al-Mehdi, Chun Song, Brian B. Hasinoff, Dwight M. Nance, Derrek Jensen, Hongming Qiu, Susan Pylypas
Publikováno v:
The American Journal of Pathology. 162:403-412
Metastatic cancer cells seed the lung via blood vessels. Because endothelial cells generate nitric oxide (NO) in response to shear stress, we postulated that the arrest of cancer cells in the pulmonary microcirculation causes the release of NO in the