Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Deron W Jones"'
Autor:
Dorothee Weihrauch, John G Krolikowski, Deron W Jones, Tahniyath Zaman, Omoshalewa Bamkole, Janine Struve, Savin Pillai, Paul S Pagel, Nicole L Lohr, Kirkwood A Pritchard
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151999 (2016)
Interferon regulatory factor 5 (IRF5) has been called a "master switch" for its ability to determine whether cells mount proinflammatory or anti-inflammatory responses. Accordingly, IRF5 should be an attractive target for therapeutic drug development
Externí odkaz:
https://doaj.org/article/c9747cfa4b5b42a0ae1f8cd9bcc8f2e0
Autor:
Hao Xu, John G Krolikowski, Deron W Jones, Zhi-Dong Ge, Paul S Pagel, Kirkwood A Pritchard, Dorothée Weihrauch
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52046 (2012)
The apoAI mimetic 4F was designed to inhibit atherosclerosis by improving HDL. We reported that treating tight skin (Tsk(-/+)) mice, a model of systemic sclerosis (SSc), with 4F decreases inflammation and restores angiogenic potential in Tsk(-/+) hea
Externí odkaz:
https://doaj.org/article/bf04719fe615464c9728028c3033cd84
Publikováno v:
Free Radical Biology and Medicine. 113:157-164
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors, e.g. diabetes mellitus, cause endothelial dysfunction secondary to decreased nitric oxide (NO)
Autor:
John G. Krolikowski, Dustin P. Martin, Deron W. Jones, Kirkwood A. Pritchard, Stephen Naylor, Dorothee Weihrauch, Janine A. Struve
Publikováno v:
Diabetes & Vascular Disease Research
Objective: Diabetes mellitus is a significant risk factor for peripheral artery disease. Diabetes mellitus induces chronic states of oxidative stress and vascular inflammation that increase neutrophil activation and release of myeloperoxidase. The go
Autor:
John G. Krolikowski, Kirkwood A. Pritchard, Paul S. Pagel, Omoshalewa Bamkole, Dorothee Weihrauch, Janine A. Struve, Nicole L. Lohr, Tahniyath Zaman, Deron W. Jones
Publikováno v:
Journal of Visualized Experiments.
The interferon regulatory factor 5 (IRF5) is crucial for cells to determine if they respond in a pro-inflammatory or anti-inflammatory fashion. IRF5's ability to switch cells from one pathway to another is highly attractive as a therapeutic target. W
Publikováno v:
Free Radical Biology and Medicine. 131:443
Autor:
Hao Zhang, Hao Xu, Dorothee Weihrauch, Deron W. Jones, Xigang Jing, Yang Shi, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 3009-3015 (2013)
Activated leukocytes and polymorphonuclear neutrophils (PMN) release myeloperoxidase (MPO), which binds to endothelial cells (EC), is translocated, and generates oxidants that scavenge nitric oxide (NO) and impair EC function. To determine whether MP
Autor:
Xigang Jing, David M. Gourlay, Yang Shi, Weiling Wang, Deron W. Jones, Kirkwood A. Pritchard, Dorothee Weihrauch, Hao Zhang, Tongju Guan, Cheryl A. Hillery, Jianhai Du, Keith T. Oldham, Hao Xu
Publikováno v:
Journal of Lipid Research. 54:3016-3029
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Autor:
Xigang Jing, Kirkwood A. Pritchard, Dorothee Weihrauch, Keith T. Oldham, Deron W. Jones, Hao Xu, Hao Zhang, Yang Shi, David M. Gourlay, Cheryl A. Hillery
Publikováno v:
Journal of Lipid Research. 54:3009-3015
Activated leukocytes and polymorphonuclear neutrophils (PMN) release myeloperoxidase (MPO), which binds to endothelial cells (EC), is translocated, and generates oxidants that scavenge nitric oxide (NO) and impair EC function. To determine whether MP
Publikováno v:
Journal of Neuroinflammation
Background Oxidative stress plays an important and causal role in the mechanisms by which ischemia/reperfusion (I/R) injury increases brain damage after stroke. Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for li