Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Deron W Jones"'
Autor:
Dorothee Weihrauch, John G Krolikowski, Deron W Jones, Tahniyath Zaman, Omoshalewa Bamkole, Janine Struve, Savin Pillai, Paul S Pagel, Nicole L Lohr, Kirkwood A Pritchard
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151999 (2016)
Interferon regulatory factor 5 (IRF5) has been called a "master switch" for its ability to determine whether cells mount proinflammatory or anti-inflammatory responses. Accordingly, IRF5 should be an attractive target for therapeutic drug development
Externí odkaz:
https://doaj.org/article/c9747cfa4b5b42a0ae1f8cd9bcc8f2e0
Autor:
Hao Xu, John G Krolikowski, Deron W Jones, Zhi-Dong Ge, Paul S Pagel, Kirkwood A Pritchard, Dorothée Weihrauch
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52046 (2012)
The apoAI mimetic 4F was designed to inhibit atherosclerosis by improving HDL. We reported that treating tight skin (Tsk(-/+)) mice, a model of systemic sclerosis (SSc), with 4F decreases inflammation and restores angiogenic potential in Tsk(-/+) hea
Externí odkaz:
https://doaj.org/article/bf04719fe615464c9728028c3033cd84
Autor:
Hao Zhang, Xigang Jing, Yang Shi, Hao Xu, Jianhai Du, Tongju Guan, Dorothee Weihrauch, Deron W. Jones, Weiling Wang, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 3016-3029 (2013)
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Externí odkaz:
https://doaj.org/article/ea916cdff05b4e8b905ac1c011947594
Autor:
Hao Zhang, Hao Xu, Dorothee Weihrauch, Deron W. Jones, Xigang Jing, Yang Shi, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 3009-3015 (2013)
Activated leukocytes and polymorphonuclear neutrophils (PMN) release myeloperoxidase (MPO), which binds to endothelial cells (EC), is translocated, and generates oxidants that scavenge nitric oxide (NO) and impair EC function. To determine whether MP
Externí odkaz:
https://doaj.org/article/588656a33fe543a18bcd6e1e6e63105c
Autor:
Weiling Wang, Hao Xu, Yang Shi, Sandhya Nandedkar, Hao Zhang, Haiqing Gao, Thom Feroah, Dorothee Weihrauch, Marie L. Schulte, Deron W. Jones, Jason Jarzembowski, Mary Sorci-Thomas, Kirkwood A. Pritchard, Jr.
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2560-2570 (2010)
The relationship between high-density lipoprotein and pulmonary function is unclear. To determine mechanistic relationships we investigated the effects of genetic deletion of apolipoprotein A-I (apoA-I) on plasma lipids, paraoxonase (PON1), pro-infla
Externí odkaz:
https://doaj.org/article/876296480b024f488959d8d3ac524e4c
Publikováno v:
Free Radical Biology and Medicine. 113:157-164
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors, e.g. diabetes mellitus, cause endothelial dysfunction secondary to decreased nitric oxide (NO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f26a8019bef9c52c0ea6909f3e78dd
https://doi.org/10.1016/j.freeradbiomed.2017.09.012
https://doi.org/10.1016/j.freeradbiomed.2017.09.012
Autor:
John G. Krolikowski, Dustin P. Martin, Deron W. Jones, Kirkwood A. Pritchard, Stephen Naylor, Dorothee Weihrauch, Janine A. Struve
Publikováno v:
Diabetes & Vascular Disease Research
Objective: Diabetes mellitus is a significant risk factor for peripheral artery disease. Diabetes mellitus induces chronic states of oxidative stress and vascular inflammation that increase neutrophil activation and release of myeloperoxidase. The go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1813b985ec2cbe08062d546c0788c7ec
https://doi.org/10.1177/1479164120907971
https://doi.org/10.1177/1479164120907971
Autor:
John G. Krolikowski, Kirkwood A. Pritchard, Paul S. Pagel, Omoshalewa Bamkole, Dorothee Weihrauch, Janine A. Struve, Nicole L. Lohr, Tahniyath Zaman, Deron W. Jones
Publikováno v:
Journal of Visualized Experiments.
The interferon regulatory factor 5 (IRF5) is crucial for cells to determine if they respond in a pro-inflammatory or anti-inflammatory fashion. IRF5's ability to switch cells from one pathway to another is highly attractive as a therapeutic target. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e8f2443488747a3a8ad0f40b83434d
https://doi.org/10.3791/55036
https://doi.org/10.3791/55036
Publikováno v:
Free Radical Biology and Medicine. 131:443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bcdf2a52bd7afc801b08d3ee6eb5141
https://doi.org/10.1016/j.freeradbiomed.2018.12.007
https://doi.org/10.1016/j.freeradbiomed.2018.12.007
Autor:
Xigang Jing, David M. Gourlay, Yang Shi, Weiling Wang, Deron W. Jones, Kirkwood A. Pritchard, Dorothee Weihrauch, Hao Zhang, Tongju Guan, Cheryl A. Hillery, Jianhai Du, Keith T. Oldham, Hao Xu
Publikováno v:
Journal of Lipid Research. 54:3016-3029
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd945f343d01d90be3c98e2222812957
https://doi.org/10.1194/jlr.m038273
https://doi.org/10.1194/jlr.m038273