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Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Autor: Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay B., Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Michaud, Henri-Alexandre, Delpech, Helène, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, du Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

Publikováno v: Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer, London : BioMed Central, 2013-, 2019, 7 (1), pp.29-46. ⟨10.1186/s40425-019-0498-z⟩
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2019, 7 (1), pp.29-46. ⟨10.1186/s40425-019-0498-z⟩
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2019, 7, ⟨10.1186/s40425-019-0498-z⟩
Journal for Immunotherapy of Cancer, 2019, 7 (1), pp.29-46. ⟨10.1186/s40425-019-0498-z⟩
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)

Background Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an excitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bca18e4c94c133e53f8bd8b563f10c40
http://europepmc.org/articles/PMC6360707

Additional file 4: of Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Autor: Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay, Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Henri-Alexandre Michaud, Helène Delpech, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

Figure S3. Representative image of cath-D expression in TNBC biopsies. Cath-D expression was monitored by IHC using monoclonal anti-human cath-D (C-5; sc-377127) antibody in TMA. Staining is prominent in breast cancer cells and is also detected in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6121577de3a4a34fa24b459f0ac5b65d

Additional file 3: of Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Autor: Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay, Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Henri-Alexandre Michaud, Helène Delpech, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

Figure S2. Schematic overview of the biotinylation method used for the identification of accessible proteins in TNBC samples.The technique involves the biotinylation of TNBC biopsies by immersion in the chemically modified biotin solution. Proteins a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e6199e2b2ee18146c3b9be3b17e33

Additional file 7: of Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Autor: Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay, Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Henri-Alexandre Michaud, Helène Delpech, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle

Figure S6. Biodistribution analysis of anti-cath-D F1 and E2 human antibodies. Nude mice bearing subcutaneous MDA-MB-231 tumor cell xenografts received one injection of 177Lu- F1 (upper panel) or 177Lu- E2 (lower panel). The percentage of injected ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a1e0f9d83fbc7ff5af740974f8b7f1