Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Dermot F. Mcginnity"'
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285798 (2023)
The exposure of a dendritic nanoparticle and its conjugated active pharmaceutical ingredient (API) was determined in mouse, rat and dog, with the aim of investigating interspecies differences facilitating clinical translation. Plasma area under the c
Externí odkaz:
https://doaj.org/article/7db92a8cdaa54db4869c9ca4393d7542
Autor:
Srinivasan Krishnan, Diane Ramsden, Douglas Ferguson, Simone H. Stahl, Joanne Wang, Dermot F. McGinnity, Niresh Hariparsad
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:562-572
Transporters contribute to renal elimination of drugs; therefore drug disposition can be impacted if transporters are inhibited by comedicant drugs. Regulatory agencies have provided guidelines to assess potential drug-drug interaction (DDI) risk for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591761a554a12b03335024347cf8a4ee
https://doi.org/10.1002/cpt.2666
https://doi.org/10.1002/cpt.2666
Autor:
Dermot F. McGinnity, Ken Grime
Publikováno v:
The Handbook of Medicinal Chemistry ISBN: 9781788018982
An acceptable human pharmacokinetic profile increases the probability of a promising candidate drug becoming a successful therapy. The development of a mechanistic understanding of the disposition of candidate drugs towards confident predictions of k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0108ba2d433681f48f4fa6ede8eb0f
https://doi.org/10.1039/9781788018982-00298
https://doi.org/10.1039/9781788018982-00298
Autor:
Tamara D. Cabalu, Mengyao Li, Kenichi Umehara, Dermot F. McGinnity, Neil Parrott, Kunal S Taskar, Arian Emami Riedmaier, Micaela B Reddy, Hugues Chanteux, Martin E. Dowty, Justine Badée, Jialin Mao, Jayaprakasam Bolleddula, Loeckie de Zwart, Jessica Rehmel, Dwaipayan Mukherjee, Chandra Prakash, Niresh Hariparsad, Masakatsu Kotsuma, Diane Ramsden, Karthik Venkatakrishnan, Venkatesh Pilla Reddy, Kushal Shah
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:770-781
The International Consortium for Innovation and Quality (IQ) Physiologically Based Pharmacokinetic (PBPK) Modeling Induction Working Group (IWG) conducted a survey across participating companies around general strategies for PBPK modeling of inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdb2828c5120894f449c5ff5d05acce
https://doi.org/10.1002/cpt.2503
https://doi.org/10.1002/cpt.2503
Autor:
Christina Vasalou, Douglas Ferguson, Weimin Li, Victorine Muse, Francis D. Gibbons, Silvia Sonzini, Guangnong Zhang, Petar Pop-Damkov, Eric Gangl, Srividya B. Balachander, Shenghua Wen, Alwin G. Schuller, Sanyogitta Puri, Mariarosa Mazza, Marianne Ashford, Adrian J. Fretland, Dermot F. McGinnity, Rhys D. O. Jones
Publikováno v:
Molecular Pharmaceutics. 19:172-187
A physiologically based pharmacokinetic model was developed to describe the tissue distribution kinetics of a dendritic nanoparticle and its conjugated active pharmaceutical ingredient (API) in plasma, liver, spleen, and tumors. Tumor growth data fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7b0f94146be1337e6d4c7f1e094eb4
https://doi.org/10.1021/acs.molpharmaceut.1c00715
https://doi.org/10.1021/acs.molpharmaceut.1c00715
Autor:
Dermot F. McGinnity, Diansong Zhou, Shringi Sharma, Buyun Chen, Venkatesh Pilla Reddy, Karthick Vishwanathan, Adrian J. Fretland, Joseph Ware, Yan Xu
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Limited information is available regarding the drug–drug interaction (DDI) potential of molecular targeted agents and rituximab plus cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone (R-CHOP) therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7423484d01bb4cf3c2bc3d7963e512
https://doi.org/10.1007/s00280-021-04302-5
https://doi.org/10.1007/s00280-021-04302-5
Autor:
Tashinga E. Bapiro, Scott Martin, Stephen D Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger, Dermot F McGinnity
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012c7e50c11486943a74a394d0b4eb43
https://doi.org/10.1124/dmd.123.001323
https://doi.org/10.1124/dmd.123.001323
Publikováno v:
Drug Discovery Today. 25:1793-1800
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality with the potential to open target space not accessible to conventional small molecules via a degradation-based mechanism; however, their bifunctional nature can result in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b90be2147c5934da0dd545cc49b03
https://doi.org/10.1016/j.drudis.2020.07.013
https://doi.org/10.1016/j.drudis.2020.07.013
Publikováno v:
Drug Metabolism and Disposition. 48:1137-1146
The use of in vitro in vivo extrapolation (IVIVE) from human hepatocyte (HH) and human liver microsome (HLM) stability assays is a widely accepted predictive methodology for human metabolic clearance (CLmet). However, a systematic underprediction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee63503e9e698986d5025960432a99
https://doi.org/10.1124/dmd.120.000131
https://doi.org/10.1124/dmd.120.000131
Autor:
Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo
Publikováno v:
Journal of medicinal chemistry. 63(23)
Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER+ breast cancer. Structure based design together with systematic investigation of each region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a07ad198923d95942c131a39083de
https://pubmed.ncbi.nlm.nih.gov/32910656
https://pubmed.ncbi.nlm.nih.gov/32910656