Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dermatologic Pharmacology"'
Publikováno v:
F1000Research, Vol 6 (2017)
Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout
Externí odkaz:
https://doaj.org/article/f854ee317343479a93967b6a6e655bef
Autor:
Martin Aringer, Anne Erler
Publikováno v:
F1000Research, Vol 6 (2017)
How the main components in systemic sclerosis—namely autoimmunity, vasculopathy, and fibrosis—fit together is still not sufficiently clear. However, vascular treatment options are well established, the body of evidence for the efficacy of immunom
Externí odkaz:
https://doaj.org/article/43507156243e46229eacb8be66b88eec
Autor:
Nina A. Ran, Aimee S. Payne
Publikováno v:
F1000Research, Vol 6 (2017)
Rituximab, a monoclonal antibody targeting the B cell marker CD20, was initially approved in 1997 by the United States Food and Drug Administration (FDA) for the treatment of non-Hodgkin lymphoma. Since that time, rituximab has been FDA-approved for
Externí odkaz:
https://doaj.org/article/e6edce74f5314baf8ef31d84931359b0
Autor:
Dafna D. Gladman
Publikováno v:
F1000Research, Vol 5 (2016)
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who prese
Externí odkaz:
https://doaj.org/article/aa31e18c9dcd4f95bb4e98587df76ff1
Publikováno v:
F1000Research, Vol 5 (2016)
Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization. Recent advances have shed light on key components that drive disease onset and progression as wel
Externí odkaz:
https://doaj.org/article/95d19ee336f342c593d1425e116089a5
Publikováno v:
F1000Research, Vol 5 (2016)
Duchenne muscular dystrophy (DMD) is a recessive lethal inherited muscular dystrophy caused by mutations in the gene encoding dystrophin, a protein required for muscle fibre integrity. So far, many approaches have been tested from the traditional gen
Externí odkaz:
https://doaj.org/article/54357fc4668d42519d992c027de11afd
Publikováno v:
F1000Research, Vol 5 (2016)
Chronic itch is a significant health burden with few effective treatments. As such, itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment. The field of itch research is dynamic, and many advances h
Externí odkaz:
https://doaj.org/article/e86a5f6704f147b8adb0a711530ebdc2
Autor:
James A. Timmons, Iain J. Gallagher
Publikováno v:
F1000Research, Vol 5 (2016)
The purpose of an F1000 review is to reflect on the bigger picture, exploring controversies and new concepts as well as providing opinion as to what is limiting progress in a particular field. We reviewed about 200 titles published in 2015 that inclu
Externí odkaz:
https://doaj.org/article/49990a91896d46cfa2646eb5a3780799
Autor:
Iwei Yeh
Publikováno v:
F1000Research, Vol 5 (2016)
According to the multi-step carcinogenesis model of cancer, initiation results in a benign tumor and subsequent genetic alterations lead to tumor progression and the acquisition of the hallmarks of cancer. This article will review recent discoveries
Externí odkaz:
https://doaj.org/article/2c5bf74aeba44e03959908c96825ceb3
Autor:
Wolfram Hoetzenecker, Tarun Mehra, Ieva Saulite, Martin Glatz, Peter Schmid-Grendelmeier, Emmanuella Guenova, Antonio Cozzio, Lars E. French
Publikováno v:
F1000Research, Vol 5 (2016)
Toxic epidermal necrolysis (TEN) is a rare, life-threatening drug-induced skin disease with a mortality rate of approximately 30%. The clinical hallmark of TEN is a marked skin detachment caused by extensive keratinocyte cell death associated with mu
Externí odkaz:
https://doaj.org/article/47ac3b3fd53e4f57aed57587201965cd