Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Derksen DR"'
1
Akademický článek
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Autor: Griffith DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Fortin JP; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kuzmiski JB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Loria PM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Saxena AR; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Bagley SW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Buckeridge C; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Curto JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Derksen DR; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Dias JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Griffor MC; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Han S; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Jackson VM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Landis MS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Lettiere D; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Limberakis C; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Liu Y; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Mathiowetz AM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Patel JC; Sosei Heptares, Cambridge CB21 6DG, U.K., Piotrowski DW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Price DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Ruggeri RB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Tess DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8208-8226. Date of Electronic Publication: 2022 Jun 01.
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2
Akademický článek
Correction for St-Denis et al., "Evidence for Regulation of Mitotic Progression through Temporal Phosphorylation and Dephosphorylation of CK2α".
Autor: St-Denis NA; Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1., Derksen DR; Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1., Litchfield DW; Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.; Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.
Publikováno v: Molecular and cellular biology [Mol Cell Biol] 2021 Jul 23; Vol. 41 (8), pp. e0027421. Date of Electronic Publication: 2021 Jul 23.
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3
Akademický článek
Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
Autor: Plisson F; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., Hill TA; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: t.hill@imb.uq.edu.au., Mitchell JM; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., Hoang HN; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., de Araujo AD; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., Xu W; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., Cotterell A; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia., Edmonds DJ; Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States., Stanton RV; Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States., Derksen DR; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, CT 06340, United States., Loria PM; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, CT 06340, United States., Griffith DA; Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States., Price DA; Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States., Liras S; Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States., Fairlie DP; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: d.fairlie@imb.uq.edu.au.
Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2017 Feb 15; Vol. 127, pp. 703-714. Date of Electronic Publication: 2016 Oct 21.
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4
Akademický článek
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
Autor: Swedberg JE; From the Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia., Schroeder CI; From the Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia., Mitchell JM; From the Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia., Fairlie DP; From the Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia., Edmonds DJ; Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139, and., Griffith DA; Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139, and., Ruggeri RB; Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139, and., Derksen DR; Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut 06340., Loria PM; Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut 06340., Price DA; Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139, and., Liras S; Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139, and., Craik DJ; From the Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia, d.craik@imb.uq.edu.au.
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Jul 22; Vol. 291 (30), pp. 15778-87. Date of Electronic Publication: 2016 May 10.
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5
Akademický článek
Optimization of amide-based EP3 receptor antagonists.
Autor: Lee EC; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Cambridge, MA 02139, United States. Electronic address: esther.lee2@pfizer.com., Futatsugi K; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Cambridge, MA 02139, United States., Arcari JT; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Groton, CT 06340, United States., Bahnck K; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Groton, CT 06340, United States., Coffey SB; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Groton, CT 06340, United States., Derksen DR; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, Groton, CT 06340, United States., Kalgutkar AS; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Cambridge, MA 02139, United States., Loria PM; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, Groton, CT 06340, United States., Sharma R; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, Groton, CT 06340, United States.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Jun 01; Vol. 26 (11), pp. 2670-5. Date of Electronic Publication: 2016 Apr 09.
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6
Akademický článek
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7
Akademický článek
Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.
Autor: Swedberg JE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia., Schroeder CI; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia., Mitchell JM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia., Durek T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia., Fairlie DP; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia., Edmonds DJ; Worldwide Medicinal Chemistry, CVMED, Pfizer Inc., Cambridge, MA, USA., Griffith DA; Worldwide Medicinal Chemistry, CVMED, Pfizer Inc., Cambridge, MA, USA., Ruggeri RB; Worldwide Medicinal Chemistry, CVMED, Pfizer Inc., Cambridge, MA, USA., Derksen DR; Pharmacokinetics, Dynamics and Metabolism, Worldwide Research & Development, Pfizer Inc., Groton, CT, USA., Loria PM; Pharmacokinetics, Dynamics and Metabolism, Worldwide Research & Development, Pfizer Inc., Groton, CT, USA., Liras S; Worldwide Medicinal Chemistry, CVMED, Pfizer Inc., Cambridge, MA, USA., Price DA; Worldwide Medicinal Chemistry, CVMED, Pfizer Inc., Cambridge, MA, USA., Craik DJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 QLD, Australia. Electronic address: d.craik@imb.uq.edu.au.
Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2015 Oct 20; Vol. 103, pp. 175-84. Date of Electronic Publication: 2015 Aug 29.
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8
Akademický článek
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
Autor: Hoang HN; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia., Song K, Hill TA; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia., Derksen DR, Edmonds DJ, Kok WM; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia., Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia., Piotrowski DW, Price DA, Stanton RV, Suen JY; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia., Withka JM, Griffith DA, Fairlie DP; †Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 4080-5. Date of Electronic Publication: 2015 Apr 16.
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9
Akademický článek
Exome sequencing in 16 patients with pituitary stalk interruption syndrome: A monocentric study.
Autor: Brauner, Raja1 (AUTHOR) raja.brauner@wanadoo.fr, Bignon-Topalovic, Joelle2 (AUTHOR), Bashamboo, Anu2 (AUTHOR), McElreavey, Ken2 (AUTHOR)
Publikováno v: PLoS ONE. 12/14/2023, Vol. 18 Issue 12, p1-11. 11p.
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10
Akademický článek
Characterization of [¹²⁵I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta.
Autor: Kuc RE; Clinical Pharmacology Unit, Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Maguire JJ; Clinical Pharmacology Unit, Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Siew K; Clinical Pharmacology Unit, Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Patel S; Pfizer, Cardiovascular Medicine, Cambridge, MA, USA., Derksen DR; Pfizer, Cardiovascular Medicine, Cambridge, MA, USA., Margaret Jackson V; Pfizer, Cardiovascular Medicine, Cambridge, MA, USA., O'Shaughnessey KM; Clinical Pharmacology Unit, Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Davenport AP; Clinical Pharmacology Unit, Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: apd10@medschl.cam.ac.uk.
Publikováno v: Life sciences [Life Sci] 2014 May 02; Vol. 102 (2), pp. 134-8. Date of Electronic Publication: 2014 Mar 15.
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