Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Derk J. Bergsma"'
Autor:
Jeffrey M. Stadel, Henry M. Sarau, Shelagh Wilson, Jeffrey S. Culp, Brian D. Hellmig, James J. Foley, Janet Park, Alison I. Muir, Jon K. Chambers, Robert S. Ames, J. Randall Slemmon, Dean E. McNulty, Derk J. Bergsma
Publikováno v:
G Protein-Coupled Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b48a2934c1ac3991b17c7c9fc6b9365
https://doi.org/10.1201/9780429129377-4
https://doi.org/10.1201/9780429129377-4
Autor:
Vawter L, Derk J. Bergsma, Xiang Li, Shelagh Wilson, Robert S. Ames, Tierney La, Alston J, Boyce R, Hsiao-Ling Wu, Zhu Y, Henry M. Sarau, Fitzgerald Lr, George M. Dytko, Mannan Ij, J.P. Hieble, Nicole C. Herrity, Davenport Cm, Michalovich D, Tan Kb
Publikováno v:
Molecular Pharmacology. 59:434-441
Using a genomics-based reverse pharmacological approach for screening orphan G-protein coupled receptors, we have identified and cloned a novel high-affinity histamine receptor. This receptor, termed AXOR35, is most closely related to the H3 histamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8275e15c20f6649c1e6e629a7aa2a9
https://doi.org/10.1124/mol.59.3.434
https://doi.org/10.1124/mol.59.3.434
Autor:
Jon K. Chambers, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Nabil Elshourbagy, Usman Shabon, Dulcie B. Schmidt, George M. Dytko, Nicholas A. Evans, Derk J. Bergsma, Robert S. Ames, Kong B. Tan, Henry M. Sarau, Da Yuan Wang, Graeme Milligan, D. Alex Groarke, Peter T. Buckley, Paul R. Murdock, James J. Foley, Parvathi Nuthulaganti
Publikováno v:
Journal of Biological Chemistry. 275:25965-25971
Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5cafd790b16038f625a65339c455f1
https://doi.org/10.1074/jbc.m004515200
https://doi.org/10.1074/jbc.m004515200
Autor:
Anne M. Romanic, Douglas W. P. Hay, Shelagh Wilson, Eliot H. Ohlstein, Nambi Aiyar, Calvert Louden, Wu-Schyong Liu, Henry M. Sarau, George I. Glover, Stephen A. Douglas, Stephen Dudley Holmes, Charles F. Sauermelch, Nabil Elshourbagy, Usman Shabon, John D. Martin, Robert W. Coatney, James J. Foley, Johathan K. Chambers, Derk J. Bergsma, Catherine E. Ellis, Dean E. McNulty, Robert S. Ames, John J. Trill, Zhaohui Ao, Robert N. Willette, Jeffrey M. Stadel, Jyoti Disa
Publikováno v:
Nature. 401:282-286
Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords1,2, and which has recently been cloned from man3. Here we describe the identification of an orphan human G-protein-coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f6a769e8aa255ebc1716ff22de776
https://doi.org/10.1038/45809
https://doi.org/10.1038/45809
Autor:
Peter T. Buckley, Paul R. Murdock, Catherine E. Ellis, Nabil Elshourbagy, Owen Jenkins, Douglas W. P. Hay, Nicole C. Herrity, Ganesh M. Sathe, James J. Foley, Alison I. Muir, Parvathi Nuthulaganti, Jon K. Chambers, Shelagh Wilson, Roseanna M. Muccitelli, George M. Dytko, Wendy S. Halsey, Dulcie B. Schmidt, Henry M. Sarau, Derk J. Bergsma, Robert S. Ames
Publikováno v:
Molecular Pharmacology. 56:657-663
The cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory disorders, in particular asthma, for which the CysLT receptor antagonists pranlukast, zafirlukast, and montelukast, have been introduced recently as novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b162a4b722162fccd8a0083f840edb
https://doi.org/10.1124/mol.56.3.657
https://doi.org/10.1124/mol.56.3.657
Autor:
Nicole C. Herrity, Catherine E. Ellis, Alison I. Muir, Jeffrey M. Stadel, Jon K. Chambers, Shelagh Wilson, Paul R. Murdock, Kenneth G. M. Fantom, Derk J. Bergsma
Publikováno v:
British Journal of Pharmacology. 125:1387-1392
The pharmaceutical industry has readily embraced genomics to provide it with new targets for drug discovery. Large scale DNA sequencing has allowed the identification of a plethora of DNA sequences distantly related to known G protein-coupled recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f9aee8845a369010efb0a7487a6b38
https://doi.org/10.1038/sj.bjp.0702238
https://doi.org/10.1038/sj.bjp.0702238
Autor:
Nabil Elshourbagy, Subinay Ganguly, Joyce Mao, Nambi Aiyar, Jyoti Disa, Ann M. Swift, Derk J. Bergsma, John E. Adamou
Publikováno v:
Endocrinology. 139:1678-1683
Calcitonin gene-related peptide (CGRP) receptors (CGRP-Rs) are widely distributed throughout the central and peripheral nervous systems. A novel CGRP-R was identified from a porcine lung complementary DNA library. Sequence analysis indicated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732caa266a55dfee0edc4b4a3cc0e1b1
https://doi.org/10.1210/endo.139.4.5860
https://doi.org/10.1210/endo.139.4.5860
Autor:
Nabil Elshourbagy, Richard M. Chemelli, Roland S. Annan, Wu Schyong Liu, Jonathan R.S. Arch, S. Clay Williams, Makoto Ishii, Masashi Yanagisawa, Shelagh Wilson, Robin E. Buckingham, Akira Amemiya, Derk J. Bergsma, Jonathan A. Terrett, Ichiyo Matsuzaki, Gerald P. Kozlowski, Takeshi Sakurai, Steven A. Carr, Andrea C. Haynes, Hirokazu Tanaka, Dean E. McNulty, James A. Richardson
Publikováno v:
Scopus-Elsevier
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320836d1dc2ad7cc540df80075335a66
Publikováno v:
Trends in Pharmacological Sciences. 18:430-437
Access to DNA databases has introduced an exciting new dimension to the way biomedical research is conducted. `Genomic research' offers tremendous opportunity for accelerating the identification of the cause of disease at the molecular level and ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b219a35105431f2c5b057ed7054a8a5
https://doi.org/10.1016/s0165-6147(97)01117-6
https://doi.org/10.1016/s0165-6147(97)01117-6
Autor:
Yunjun Ai, S Van Horn, Derk J. Bergsma, William R. Skach, E. Anoia, Dwight Stambolian, K Nesburn
Publikováno v:
Genome Research. 6:980-985
Defects in the human GALK1 gene result in galactokinase deficiency and cataract formation. We have isolated this gene and established its structural organization. The gene contains 8 exons and spans approximately 7.3 kb of genomic DNA. The GALK1 prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5d80f0bc645c2ba07c46a0cb2a7d44
https://doi.org/10.1101/gr.6.10.980
https://doi.org/10.1101/gr.6.10.980